Characterization of Auditory Processing Involved in the Encoding of Speech Sounds

NCT02574299 | Completed

• 2 other identifiers: 2013-796ID-RCB
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

The ability to encode the speech signal is determined by ascending and descending auditory processing. Difficulties in processing these speech signals are well described at the behavioral level in a specific language disorder. However, little is known about the underlying pathophysiological mechanisms. The assumption is that we should observe a degradation of the signal provided by the ear in the deaf subject while in case of specific language impairment it would be a phonemic disorder (possibly linked to a processing disorder auditory). The two population groups should therefore have different abnormalities of their central auditory process - which could be modified by the target remediation for each group.

Conditions

Language Impairment; Hearing Loss

Keywords

dyslexia; training; auditory rehabilitation; hearing loss; evoked potentials; dichotic; plasticity; noise

Outcome Measures

Primary Outcomes (1)

• Change from Baseline speech auditory brainstem and late responses (composite and objective measure) in response to syllables (behavioral measure)

  Spectro-temporal analysis of speech auditory brainstem and late responses : The speech brainstem and cortical responses are simultaneously obtained in response of different selected syllables from a continuum (selected by using a phonemic identification test) which is presented throughout a behavioral categorical procedure

  Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline

Secondary Outcomes (3)

• Change from Baseline medial olivocochlear system (MOCS) functioning measured using the contralateral suppressive effect of transient evoked otoacoustic emissions (composite measure)

  Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline

• Change from Baseline dichotic skills measured using central auditory processing tests (composite measure)

  Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline

• Change from Baseline speech-noise listening skills measured using logatomes tests (composite measure)

  Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline

Study Arms (6)

1: Normal hearing children without SLI, transversal group

NO INTERVENTION

Normal hearing children without Specific Language Impairment (SLI),Transversal group for test-retest measures

2: Normal hearing children without SLI, longitudinal group

NO INTERVENTION

Normal hearing children without Specific Language Impairment (SLI), longitudinal group without training

3: Normal hearing children with SLI, longitudinal group

OTHER

Normal hearing children with Specific Language Impairment (SLI), longitudinal group with training

Other: E-learning

4: Normal hearing adults without SLI, transversal group

NO INTERVENTION

Normal hearing adults without Specific Language Impairment (SLI), transversal group for test-retest measures

5: Normal hearing adults without SLI, longitudinal group

NO INTERVENTION

Normal hearing adults without Specific Language Impairment (SLI), longitudinal group without hearing aids (HA)

6: Hearing Impaired candidates for HA, longitudinal group

OTHER

Hearing Impaired adult candidates for hearing aids (HA), longitudinal group with hearing aids (HA)

Device: Hearing aids fitting

Interventions

E-learning OTHER

Management of auditory processing disorders with serious game (E-learning)

3: Normal hearing children with SLI, longitudinal group

Hearing aids fitting DEVICE

Symmetrical hearing loss which are fitted with binaural hearing aids for the first time

6: Hearing Impaired candidates for HA, longitudinal group

Eligibility Criteria

• Age: 6 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• For all subjects:
• native French speaker
• no medical treatment for behavior or neurological disorders
• normal or corrected vision
• right-handed
• normal otorhinolaryngology examination
• valid affiliation to social security
• no participation to another research study
• For the normal-hearing subjects
• normal tonal hearing thresholds
• normal tympanometry
• For the subjects without specific language impairment
• aged from 6 ro 40
• normal school attendance without scholastic retardation
• normal intellectual level

You may not qualify if:

• non signed assent
• treatment for depression, epilepsy, Parkinson's or alzheimer's disease during more than 6 months
• physical health deficiency
• mental retardation
• neurological or psychiatric disease incompatible with testing procedure
• For children
• known problem of hearing loss or chronic middle ear disease whic compromized the hearing status
• schooling in a foreign language
• foreign language spoken at home with both parents

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Sercive d'Audiologie et d'Exploration Orofaciales, Hôpital Edouard Herriot, Hospices Civils de Lyon

Lyon, 69003, France

Location

Related Publications (3)

• Reynard P, Veuillet E, Thai-Van H. Paradoxical and labile medial olivocochlear functioning as a potential marker of auditory processing disorder in a child with learning disabilities. Eur Ann Otorhinolaryngol Head Neck Dis. 2020 Sep;137(4):339-342. doi: 10.1016/j.anorl.2020.03.005. Epub 2020 Apr 1.

  PMID: 32247718 RESULT

• Bellier L, Bouchet P, Jeanvoine A, Valentin O, Thai-Van H, Caclin A. Topographic recordings of auditory evoked potentials to speech: subcortical and cortical responses. Psychophysiology. 2015 Apr;52(4):594-9. doi: 10.1111/psyp.12369. Epub 2014 Oct 20.

  PMID: 25329609 RESULT

• Bellier L, Veuillet E, Vesson JF, Bouchet P, Caclin A, Thai-Van H. Speech Auditory Brainstem Response through hearing aid stimulation. Hear Res. 2015 Jul;325:49-54. doi: 10.1016/j.heares.2015.03.004. Epub 2015 Mar 27.

  PMID: 25828076 RESULT

MeSH Terms

Conditions

Language Disorders; Hearing Loss; Dyslexia

Condition Hierarchy (Ancestors)

Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Specific Learning Disorder; Learning Disabilities; Neurodevelopmental Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 14, 2015
• First Posted: October 12, 2015
• Study Start: October 16, 2014
• Primary Completion: March 1, 2018
• Study Completion: March 1, 2018
• Last Updated: December 19, 2025

Record last verified: 2025-12

Locations

FR (1)