Life Course, HIV and Hepatitis B Among African Migrants Living in Ile-de-France

NCT02566148 | Completed

• 1 other identifier: ANRS PARCOURS
• Study Type: observational
• Target: 2,468
• Locations: 0 countries
• Sites: N/A

Brief Summary

Populations from Sub-Saharan Africa represent one of the most dynamic immigration flows in France and are among the most exposed to HIV infection and hepatitis B. The Parcours study aims to understand, among sub-Saharan African migrants, how social and individual factors combine in the course of migration and settlement in France, and influence the risk of infection, access to prevention and care, and the effectiveness of care for both HIV and hepatitis B diseases. The research was conducted in Ile-de-France, where 60% of sub-Saharan African migrants reside. It consists in a cross-sectional observational survey, using a life-event history approach that reproduces the sequence of different life and health events, and contributes to explain the present situation (type of disease management, patient's quality of life) in light of all the elements of the past trajectory (administrative, familial, socio-economic, professionals). A representative survey was conducted between February 2012 and May 2013 in health care facilities in Ile-de-France, among three groups of migrants from Sub-Saharan Africa: a group living with HIV, a group living with chronic hepatitis B and a group who has neither of these diseases. For each group, stratified random sampling was used. The survey was conducted in 24 hospital services providing HIV care, 20 health care facilities providing hepatitis B care, and 30 primary health care facilities. Were eligible all patients attending these health care facilities, born in a Sub-Saharan African country and with Sub-Saharan African citizenship at birth, aged 18 to 59 years, with an HIV diagnosis (HIV group) or chronic hepatitis B diagnosis (hepatitis B group) more than three months prior or not diagnosed with HIV or chronic Hepatitis B (reference group). Among the patients offered participation, 926 HIV-infected patients, 779 patients infected by hepatitis B, and 763 patients without these two diseases participated in the study. For all participants, detailed information on socio-demographic characteristics; migration and life conditions in France; social, sexual and reproductive life history; and screening and care history were collected using a life-event history questionnaire administered face-to-face by a specialized interviewer. Health care professionals documented clinical information from the medical records. Data was collected anonymously.

Conditions

HIV Infection; Chronic Hepatitis B

Keywords

Life-event survey; observational survey among migrants in France

Outcome Measures

Primary Outcomes (4)

• Lapse of time from arrival in France to HIV testing

  Time (in years) to occurence of first HIV testing, from arrival in France

  From arrival in France until the date of first HIV testing or date of of data collection, whichever came first, up to 20 years

• Lapse of time from arrival in France to hepatitis B testing

  Time (in years) to occurence of first hepatitis B testing, from arrival in France

  From arrival in France until the date of first hepatitis B testing or date of of data collection, whichever came first, up to 20 years

• Lapse of time from HIV diagnostic to access to care

  Time (in years) to occurence of entry into HIV care, from HIV diagnostic

  From first HIV diagnostic until the date of entry into care for HIV or date of of data collection, whichever came first, up to 20 years

• Lapse of time from hepatitis B diagnostic to access to care

  Time (in years) to occurence of entry into Hepatitis B care, from hepatitis B diagnostic

  From first hepatitis B diagnostic until the date of entry into care for hepatitis or date of of data collection, whichever came first, up to 20 years

Secondary Outcomes (4)

• Condom use

  twelve months before data collection

• Evolution in concurrent sexual partnerships after migration in France

  At arrival in France, and then each year up to 20 years after arrival in France

• Evolution in occasional sexual partnerships after migration in France

  At arrival in France, and then each year up to 20 years after arrival in France

• Evolution in transactional sexual partnerships after migration in France

  At arrival in France, and then each year up to 20 years after arrival in France

Study Arms (3)

HIV group

group living with HIV

Hepatitis B group

group living with chronic hepatitis B

Reference group

group who has neither HIV nor hepatitis B

Eligibility Criteria

• Age: 18 Years - 59 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Migrants from Sub-Saharan Africa living in Ile-de-France (Paris area) and visiting health care facilities: people living with HIV/AIDS (HIV group), people with chronic hepatitis B (hepatitis B group), and people who have neither of these conditions and consult within primary health care facilities in Ile-de-France (reference group).

You may qualify if:

• \- For the 3 groups:
• Be born in a Sub-Saharan African country and with Sub-Saharan African citizenship at birth,
• Visit the health care facility for one's own health.
• For the HIV group: To have been diagnosed for HIV more than 3 months ago, regardless of co-infections
• For the hepatitis B group: To have been diagnosed with a chronic hepatitis B (AgHBs+) more than 3 months ago and not be HIV co-infected
• For the primary care group: Not be known by the consulting physician as infected by HIV or Hepatitis B.

You may not qualify if:

• to have been diagnosed for HIV or hepatitis B less than 3 months ago.
• major cognitive or health impairments

Sponsors & Collaborators

• ANRS, Emerging Infectious Diseases: lead
• Ministry of Health, France: collaborator
• Institut de Recherche pour le Developpement: collaborator
• Institut National de la Santé Et de la Recherche Médicale, France: collaborator
• Institut national de prevention et d'education pour la sante: collaborator

Related Publications (3)

• Vignier N, Dray Spira R, Pannetier J, Ravalihasy A, Gosselin A, Lert F, Lydie N, Bouchaud O, Desgrees Du Lou A, Chauvin P; PARCOURS Study Group. Refusal to provide healthcare to sub-Saharan migrants in France: a comparison according to their HIV and HBV status. Eur J Public Health. 2018 Oct 1;28(5):904-910. doi: 10.1093/eurpub/cky118.

  PMID: 29982518 DERIVED

• Gosselin A, Desgrees du Lou A, Lelievre E; PARCOURS Study Group. How to use sequence analysis for life course epidemiology? An example on HIV-positive Sub-Saharan migrants in France. J Epidemiol Community Health. 2018 Jun;72(6):507-512. doi: 10.1136/jech-2017-209739. Epub 2018 Feb 2.

  PMID: 29437866 DERIVED

• Pannetier J, Ravalihasy A, Lydie N, Lert F, Desgrees du Lou A; Parcours study group. Prevalence and circumstances of forced sex and post-migration HIV acquisition in sub-Saharan African migrant women in France: an analysis of the ANRS-PARCOURS retrospective population-based study. Lancet Public Health. 2018 Jan;3(1):e16-e23. doi: 10.1016/S2468-2667(17)30211-6. Epub 2017 Nov 23.

  PMID: 29307383 DERIVED

Related Links

• web site of the Parcours study (in french)
• Click here for more information about this study : the PARCOURS survey protocol (in english)

MeSH Terms

Conditions

HIV Infections; Hepatitis B, Chronic

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Hepatitis B; Hepadnaviridae Infections; DNA Virus Infections; Hepatitis, Viral, Human; Hepatitis, Chronic; Hepatitis; Liver Diseases; Digestive System Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Annabel Desgrées du Loû, PhD

  Institute of Research for Development, France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2015
• First Posted: October 2, 2015
• Study Start: February 1, 2012
• Primary Completion: February 1, 2012
• Study Completion: May 1, 2013
• Last Updated: May 15, 2017

Record last verified: 2017-05