NCT02563080|Completed
Pancreatic Exocrine Insufficiency in Acute Pancreatitis
APPEI
Development of Pancreatic Exocrine Insufficiency After Moderately Severe or Severe Acute Pancreatitis
Loading search results
APPEI
Development of Pancreatic Exocrine Insufficiency After Moderately Severe or Severe Acute Pancreatitis
Sponsor study identifier
observational
50
1 country
1
Study Start
September 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2022
Actual (reported)Study Completion
February 2022
Actual (reported)Severe pancreatitis induces more damage in the pancreas and might therefore result reduced exocrine function leading to the insufficiency. The aim of this prospective study is to investigate development of pancreatic exocrine insufficiency in patients recovering from first attack of moderately severe or severe acute pancreatitis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2022
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 2015
Date type not reportedThis date has not been verified as actual or estimated.
September 27, 2015
Actual (reported)September 29, 2015
Actual (reported)February 2022
Actual (reported)February 2022
Actual (reported)Development of pancreatic exocrine insufficiency after first attack of moderately severe or severe acute pancreatitis confirmed by fecal elastase-1 test.
fecal elastase-1 \<200 ug/g
One year after discharging from hospital
Persistence of pancreatic exocrine insufficiency after first attack of moderately severe or severe acute pancreatitis
One year after discharging from hospital
New developments of pancreatic exocrine insufficiency after first attack of moderately severe or severe acute pancreatitis during the follow-up time
One year after discharging from hospital
30-day and hospital mortality after first attack of acute pancreatitis
30 days, hospitalization time
5-year survival after first attack of acute pancreatitis
5 years
50 patients with first attack of moderately severe or severe acute pancreatitis treated in Helsinki University Hospital.
Patients with first attack of moderately severe or severe acute pancreatitis treated in Helsinki University Hospital.
Helsinki University Hospital
Helsinki, 00029, Finland
Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013 Jan;62(1):102-11. doi: 10.1136/gutjnl-2012-302779. Epub 2012 Oct 25.
Boreham B, Ammori BJ. A prospective evaluation of pancreatic exocrine function in patients with acute pancreatitis: correlation with extent of necrosis and pancreatic endocrine insufficiency. Pancreatology. 2003;3(4):303-8. doi: 10.1159/000071768.
Fecal samples.
Leena Kylänpää, MD,PhD
Helsinki University Central Hospital
Outi Lindström, Md,PhD
Helsinki University Central Hospital
Taija Korpela, MD
Helsinki University Central Hospital
Marianne Udd, MD,PhD
Helsinki University Central Hospital
50 participants (actual enrollment reported by the registry).
First Submitted
September 27, 2015
First Posted
September 29, 2015
Study Start
September 2015
Date type not reportedThis date has not been verified as actual or estimated.
Study to Assess the Prognostic Value of the Antithrombin III in the Acute Pancreatitis (AT-PROPANC)
Contact the study team to confirm eligibility.
Lindstrom O, Lietzen E, Mentula P, Tolonen M, Siironen P, Udd M, Puolakkainen P, Kylanpaa L. Development of pancreatic exocrine insufficiency after first moderately severe or severe acute pancreatitis. Scand J Gastroenterol. 2025 Sep;60(9):921-927. doi: 10.1080/00365521.2025.2533337. Epub 2025 Jul 17.
Panu Mentula, MD,PhD
Helsinki University Central Hospital
Päivi Siironen, MD,PhD
Helsinki University Central Hospital
Matti Tolonen, MD
Helsinki University Central Hospital
Elina Lietzen, MD
Turku University Hospital
Primary Completion
February 2022
Actual (reported)Study Completion
February 2022
Actual (reported)Last Updated
August 16, 2022
Record last verified: 2022-08
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: