Study of the Impact of Changes in Carbonemia on Microcirculation in Patients Achieving a Test Hypercapnia

NCT02549378 | Completed

• 1 other identifier: 1308031
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The microcirculatory alterations is common in circulatory failure, especially during sepsis. The severity of these changes and their sustainability are responsible of multi organ failure and ultimately death. The optimization of microcirculatory flow could be a central objective of the management of patients hospitalized in intensive care. Microcirculation includes all blood vessels of a diameter smaller than 100 micrometer. It represents the largest heat exchange surface of the body and is involved in tissue oxygenation. Microcirculatory flow is conditioned by the macrocirculation (heart rate and blood pressure) and the state of the microcirculation (thrombosis, vasoconstriction ...). The role of the CO2 in regulating microcirculatory flow is little studied. A recent work of our team and the oldest work in the literature lead to believe that CO2 has a specific role in modulating microcirculatory flow. No study to date precisely studied the impact of changes in the microcirculatory flow carbonemia . The hypocapnia test is carried out in a standardized manner by inhalation of a mixture enriched in CO2 7% allows a significant increase in carbonemia. Hypocapnia will in turn obtained by a calibrated voluntary hyperventilation test. Direct visualization of microcirculation by confocal microscopy is now considered the gold standard for exploring the microcirculation.

Conditions

Microcirculation; Blood Circulation

Keywords

microcirculation; confocal microscopy; hypocapnia

Outcome Measures

Primary Outcomes (1)

• microcirculatory flow (cells / min) measured by confocal microscopy

  microcirculatory flow (cells / min) measured by confocal microscopy in hypocapnic patients

  Day1

Secondary Outcomes (1)

• microvessel diameter (micrometer) measured by confocal microscopy

  Day1

Study Arms (1)

patients with a hypercapnia test

EXPERIMENTAL

confocal microscopy patients with a hypercapnia test

Device: confocal microscopy

Interventions

confocal microscopy DEVICE

microvessel diameter measured by confocal microscopy

patients with a hypercapnia test

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients from achieving hypercapnia test the CHU of Saint-Etienne
• non smoking
• non diabetic
• affiliated with or entitled to a social security system
• Written consent

You may not qualify if:

• subjects not performing the test hypercapnia in full
• patients with dermatological pathology at the study area
• patient with Raynaud's syndrome
• Patients with known bleeding disorders
• refusal to consent

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (1)

CHU Saint-Etienne

Saint-Etienne, 42055, France

Location

MeSH Terms

Conditions

Hypocapnia

Interventions

Microscopy, Confocal

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Microscopy; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Officials

• Laurent Gergelé, MD

  CHU SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 11, 2015
• First Posted: September 15, 2015
• Study Start: May 1, 2013
• Primary Completion: June 1, 2013
• Study Completion: June 1, 2013
• Last Updated: September 15, 2015

Record last verified: 2015-09

Locations

FR (1)