NCT06872216

Brief Summary

Twenty healthy volunteers were included in the study. The NIRS was placed on the thenar region of the hand. The vascular occlusion protocol had been done before and after cupping therapy (CT). Regional oxygen saturation (rSO2), the times to the lowest and highest values were recorded. The occlusion slope, the recovery slope and the first 10 second recovery slope were calculated.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Aug 2022

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2022

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2023

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2023

Completed
1.8 years until next milestone

First Submitted

Initial submission to the registry

February 18, 2025

Completed
22 days until next milestone

First Posted

Study publicly available on registry

March 12, 2025

Completed
Last Updated

March 12, 2025

Status Verified

February 1, 2025

Enrollment Period

5 months

First QC Date

February 18, 2025

Last Update Submit

March 6, 2025

Conditions

Microcirculation

Keywords

Cupping therapymicrocirculationnear-infrared spectroscopy

Outcome Measures

Primary Outcomes (1)

  • the rSO2 values

    monitored at tenar region on the dominant hand with near infrared spectrometry

    Periprocedural

Secondary Outcomes (5)

  • the time to reach the lowest rSO2

    Periprocedural

  • the time to reach the highest values

    Periprocedural

  • the occlusion slope

    Periprocedural

  • Recovery slope

    Periprocedural

  • The 10th second recovery slope

    Periprocedural

Study Arms (1)

cupping therapy

OTHER

nırs monitored during vot test pre-post cupping therapy

Procedure: cupping therapyDiagnostic Test: Vascular occlusion test

Interventions

cupping therapyPROCEDURE

After the initial vascular occlusion test and a subsequent 10-minute rest period, the plastic therapy cup was placed on the forearm, 5 cm away from the medial and lateral epicondyles by a certified cupping therapist. The size of used cup was determined according to the size of the volunteer's forearm which cover 50% of the area. The cup was vacuumed two times full pumping with a manual hand pump and remained in place for 5 minutes. And then the air was removed by releasing the cups through the release valve.

cupping therapy
Vascular occlusion testDIAGNOSTIC_TEST

A blood pressure cuff was placed on the upper arm. The adult probe of the NIRS device (Covidien INVOS™ 5100C Cerebral/Somatic Oximeter, Dublin) was placed on the thenar region of the ipsilateral hand and the regional oxygen value was recorded during all study term. Baseline arterial pressure and oxygen saturation were monitored (GE Healthcare Oy, Helsinki, Finland) from the side of dominant hand and recorded. After a 3-minute stabilization period, the vascular occlusion protocol was started. The blood pressure cuff was rapidly inflated within 3-4 seconds to 50 mmHg above baseline systolic blood pressure and kept at this pressure during 3 minutes. Following this, the cuff was deflated within 1 second. Five minutes after cupping therapy this protocol had done again.

cupping therapy

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years old
  • Healthy

You may not qualify if:

  • Smoking or using tobacco products
  • Taking alcohol or other substances, or any medication
  • Have conditions affecting microcirculation
  • Have acute or chronic pain
  • Anemia
  • Obesity
  • Reynaud's phenomenon
  • Baseline blood pressure being 140-90mmHg or above
  • sPO2 value being below 96%

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Tokat Gaziosmanpaşa üniversity

Tokat Province, 60100, Turkey (Türkiye)

Location

Related Publications (2)

  • Liu W, Piao S, Meng Xi, Wei L. Effects of cupping on blood flow under skin of back in healthy human. World Journal of Acupuncture - Moxibustion. 2013; 23 (3): 50-52. doi.org/10.1016/S1003-5257(13)60061-6.

    BACKGROUND

  • Gomez H, Torres A, Polanco P, Kim HK, Zenker S, Puyana JC, Pinsky MR. Use of non-invasive NIRS during a vascular occlusion test to assess dynamic tissue O(2) saturation response. Intensive Care Med. 2008 Sep;34(9):1600-7. doi: 10.1007/s00134-008-1145-1. Epub 2008 Jun 4.

    PMID: 18523754BACKGROUND

MeSH Terms

Interventions

Cupping Therapy

Intervention Hierarchy (Ancestors)

Complementary TherapiesTherapeutics

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

February 18, 2025

First Posted

March 12, 2025

Study Start

August 1, 2022

Primary Completion

January 1, 2023

Study Completion

May 1, 2023

Last Updated

March 12, 2025

Record last verified: 2025-02

Data Sharing

IPD Sharing
Will not share

Locations

TU(1)