Meals and Grazing Study
MAGS
1 other identifier
interventional
15
1 country
1
Brief Summary
The purpose of this study was to determine the effects of low vs. high eating frequency (EF) on biomarkers of health and subjective appetite.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable healthy
Started Jan 2011
Typical duration for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2012
CompletedFirst Submitted
Initial submission to the registry
September 8, 2015
CompletedFirst Posted
Study publicly available on registry
September 14, 2015
CompletedSeptember 14, 2015
September 1, 2015
1.4 years
September 8, 2015
September 10, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Inflammatory biomarkers in high vs. low eating frequency conditions
Inflammatory biomarkers in high vs. low eating frequency conditions
3 weeks
Secondary Outcomes (1)
Subjective appetite in high vs. low eating frequency conditions
4 hours
Study Arms (2)
High Eating Frequency (High EF)
EXPERIMENTAL8 Eating Occasions
Low Eating Frequency (High EF)
EXPERIMENTAL3 Eating Occasions
Interventions
Free-living participants complete a 21-day high eating frequency (high EF) Phase in which they consume all daily energy at 8 eating occasions.
Free-living participants complete a 21-day low eating frequency (low EF) Phase in which they consume all daily energy at 3 eating occasions.
Eligibility Criteria
You may qualify if:
- Participants will be overweight and obese (BMI 25 and over) males and females ages 18-50 years.
- Participants must be willing to report to FHCRC on 5 occasions (initial screening appointment + 4 testing sessions)
- Participants must be willing to provide a 7-day food record for analysis prior to Phase 1 and Phase 2 of the study
- Participants must be willing to follow diet protocol during Phase 1 of the study
- Participants must be willing to undergo 4 blood draws
You may not qualify if:
- Non-diabetic (self-report)
- Non-smokers (self-report)
- Not following a diet to gain or lose weight (self-report)
- Normal cholesterol (self-report)
- Normal blood pressure (self-report)
- Not currently taking any medication (self-report)
- Not pregnant or nursing (self-report and verification by DEXA)
- Not athletes in training (self-report)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109, United States
Related Publications (1)
Perrigue MM, Drewnowski A, Wang CY, Neuhouser ML. Higher Eating Frequency Does Not Decrease Appetite in Healthy Adults. J Nutr. 2016 Jan;146(1):59-64. doi: 10.3945/jn.115.216978. Epub 2015 Nov 11.
PMID: 26561409DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Marian Neuhouser, PhD
Fred Hutchinson Cancer Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 8, 2015
First Posted
September 14, 2015
Study Start
January 1, 2011
Primary Completion
June 1, 2012
Study Completion
June 1, 2012
Last Updated
September 14, 2015
Record last verified: 2015-09