Epidemiological Study of Intestinal Colonization With Staphylococcus Aureus

NCT02547272 | Completed

• 2 other identifiers: 12080872012-A01182-41
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

Nasal colonization with S. aureus is a risk factor for infection with this bacterium. A methodologically well conducted study of S. aureus bacteremia showed that 80% of S. aureus bacteremia with are due to the strain isolated in the nasal level. However, as part of a study coordinated by the CHU of Saint-Etienne, less than 50% of infections in prosthetic orthopedic devices have been linked to nasal carriage . Outside of exogenous infections, intestinal colonization with S. aureus could be an alternative source of endogenous infections with the waning of orthopedic surgery. In the general population, considering that about one third of the subjects were colonized with S. aureus nasal level and 1 in 5 in the intestine However the proportion of exclusive intestinal porting is not well known . This study will analyze, among ICU patients, porting S. aureus nasal and rectal level. It will better clarify the relationship between nasal and rectal ports and the risk of developing an infection.

Conditions

Staphylococcus Aureus

Keywords

Intensive care; S Aureus

Outcome Measures

Primary Outcomes (1)

• prevalence of S. aureus colonization at rectal level

  The presence of a colony of S. aureus on one of the samples

  1 month

Secondary Outcomes (1)

• S. aureus strains similar to nasal and rectal level

  1 month

Study Arms (1)

Nasal and rectal samples

ICU patients with nasal and rectal bacterial samples for the presence of S Aureus

Procedure: Nasal and rectal bacterial samples

Interventions

Nasal and rectal bacterial samples PROCEDURE

Bacterial nasal and rectal samples at admission and one weekly for the presence of S Aureus

Nasal and rectal samples

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients hospitalized in intensive care

You may qualify if:

• patients hospitalized in intensive care and benefiting from a screening multiresistant bacteria in nasal and rectal level under routine care

You may not qualify if:

• refusal of the patient's family

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (1)

CHU de Saint-Etienne

Saint-Etienne, 42000, France

Location

Biospecimen

Retention: SAMPLES WITH DNA

bacterial samples

MeSH Terms

Conditions

Staphylococcal Infections

Condition Hierarchy (Ancestors)

Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections

Study Officials

• Philippe BERTHELOT, Md-PhD

  CHU SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 9, 2015
• First Posted: September 11, 2015
• Study Start: February 1, 2013
• Primary Completion: July 1, 2013
• Study Completion: July 1, 2013
• Last Updated: March 23, 2016

Record last verified: 2016-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)