Community-acquired Methicillin-Resistant Staphylococcus Aureus Carriage Among Athletes

NCT01148485 | Completed

• 1 other identifier: I09016
• Study Type: observational
• Target: 300
• Locations: 0 countries
• Sites: N/A

Brief Summary

There are only very few data about the prevalence of CA-MRSA in France and no in athletes. In USA, the clone USA300 is widely disseminated and in Europe the clone ST80 predominates. The aim of the study was to study the carriage of S. aureus in athletes in a French county (Limousin) and to evaluate the proportion of CA-MRSA. The athletes will be met during their training, each one will fill-in a clinical information questionnaire. Nasal, throat, inguinal and skin lesions swab samples will be performed. The antibiotic susceptibility profile of the Staphyloccocus aureus strains isolated will be performed as well as the detection of the PVL gene. Strains will also be typed by different molecular methods (PGFE (Pulsed Gel Field Electrophoresis), SCCmec type (Staphylococcal Chromosome Cassette mec), and MLST (MultiLocus Sequence Typing)). The CIC (Clinical Investigation Center) of the Limoges University Hospital will be in charge of the inclusions of the athletes. The sample analysis will be centralized and performed at the Laboratory of Bacteriology of the Limoges University Hospital. A Clinical Research Officer of the Limoges University Hospital will be in charge of the survey of the study and will organize monthly meetings with all the participants of the study.

Conditions

Staphylococcus Aureus

Keywords

- Staphylococcus aureus Carriage among Athletes

Outcome Measures

Primary Outcomes (1)

• Presence of Methicillin-Resistant Staphylococcus aureus in the samples.

  An athlete is defined as a carrier if at least one strain of Staphylococcus aureus is isolated from one of these samples. A MRSA carrier is defined if the resistance to methicillin has been found for the S. aureus strain isolated in the patient.

  1 year

Secondary Outcomes (1)

• Comparison of the MRSA prevalence in athletes according to the sport

  1 year

Interventions

Nasal, throat, inguinal and skin lesions swab samples will be performed OTHER

Nasal, throat, inguinal and skin lesions swab samples will be performed

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Athletes of Limousin practicing sport.

You may qualify if:

• adult patients (over 18),
• belonging to a sport club of Limousin, practicing rugby, wrestling, basket-ball, volley-ball, hand-ball, fence, martial art, football, weight lifting, and base-ball.
• Patient having signed in a free way and lit his consent to participate in this study

You may not qualify if:

• clinical information questionnaire not possible to fill,
• swab sample not possible to realize.

Sponsors & Collaborators

• University Hospital, Limoges: lead

Related Publications (1)

• Couve-Deacon E, Postil D, Barraud O, Duchiron C, Chainier D, Labrunie A, Pestourie N, Preux PM, Francois B, Ploy MC. Staphylococcus Aureus Carriage in French Athletes at Risk of CA-MRSA Infection: a Prospective, Cross-sectional Study. Sports Med Open. 2017 Aug 16;3(1):28. doi: 10.1186/s40798-017-0094-z.

  PMID: 28815486 DERIVED

MeSH Terms

Conditions

Staphylococcal Infections

Condition Hierarchy (Ancestors)

Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 16, 2010
• First Posted: June 22, 2010
• Study Start: January 1, 2011
• Primary Completion: June 1, 2011
• Study Completion: December 1, 2011
• Last Updated: November 1, 2013

Record last verified: 2010-06