Endocan Predictive Value in Postcardiac Surgery Acute Respiratory Failure.
1 other identifier
interventional
150
0 countries
N/A
Brief Summary
According to literature data, Endocan can detect the onset of respiratory failure. The investigators aim to prove its value also for cardiac surgery patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2015
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 1, 2015
CompletedStudy Start
First participant enrolled
September 1, 2015
CompletedFirst Posted
Study publicly available on registry
September 7, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2017
CompletedSeptember 7, 2015
September 1, 2015
6 months
September 1, 2015
September 3, 2015
Conditions
Outcome Measures
Primary Outcomes (1)
Changes of Endocan blood levels after cardiac surgery and its correlation with postoperative pulmonary failure
The investigators will enroll 150 patients undergoing elective cardiac surgery. Every participant will be prelevated of several blood samples following this time frame : day -1 from intervention, day 0 ( six hours after intervention), day 1 , day 2 , day 3. All patients will be observed to detect all infections, especially pulmonary ones, up to hospital discharge. Endocan blood levels of patients developing pulmonary failure and patients without postoperative respiratory insufficiency will be compared.
from day -1 of the intervention to day 3, one blood sample per day
Study Arms (1)
patients undergoing cardiac surgery
OTHERInterventions
Eligibility Criteria
You may qualify if:
- Able to give written consent
- Elective cardiac surgery
- More than 18 years old
You may not qualify if:
- Less than 18 years old
- urgency / emergency cardiac surgery
- pregnancy
- refusal
- unable to give written consent
- oncologic patients
- concomitant inflammatory or infective pulmonary disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Chazal E, Morin L, Chocron S, Lassalle P, Pili-Floury S, Salomon du Mont L, Ferreira D, Samain E, Perrotti A, Besch G. Impact of early postoperative blood glucose variability on serum endocan level in cardiac surgery patients: a sub study of the ENDOLUNG observational study. Cardiovasc Diabetol. 2023 Aug 24;22(1):221. doi: 10.1186/s12933-023-01959-5.
PMID: 37620974DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Medical Doctor
Study Record Dates
First Submitted
September 1, 2015
First Posted
September 7, 2015
Study Start
September 1, 2015
Primary Completion
March 1, 2016
Study Completion
March 1, 2017
Last Updated
September 7, 2015
Record last verified: 2015-09