The Use of Magnetic Brain Stimulation to Treat Obsessive Compulsive Disorder, a Pilot Study

NCT02541812 | Completed Results

• 1 other identifier: B2009:077
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is two-fold: first, to observe the effect of one session of repetitive transcranial magnetic stimulation (rTMS) on the error-prediction abilities of patients with obsessive compulsive disorder (OCD) as well as healthy individuals; and second, to observe the clinical effect of 10 sessions of rTMS in patients with OCD.

Conditions

Obsessive-Compulsive Disorder

Keywords

Obsessive-Compulsive Disorder; Transcranial Magnetic Stimulation; Error processing

Outcome Measures

Primary Outcomes (1)

• Change in Obsessive and Compulsive Symptom Severity (Yale-Brown Obsessive Compulsive Scale)

  Yale-Brown Obsessive Compulsive Scale. Minimum value = 0. Maximum value = 40. Higher scores indicate greater severity of obsessive and compulsive symptoms.

  Recordings: baseline; after two weeks of rTMS

Secondary Outcomes (1)

• Change in Post-error Slowing

  Recordings: baseline; after one session of rTMS

Study Arms (2)

Patients

EXPERIMENTAL

Ten sessions of 1Hz repetitive Transcranial Magnetic Stimulation of the dorsal anterior cingulate cortex in patients with obsessive compulsive disorder

Device: Transcranial Magnetic Stimulation

Healthy Control Subjects

ACTIVE COMPARATOR

One session of 1Hz repetitive Transcranial Magnetic Stimulation of the dorsal anterior cingulate cortex in healthy control individuals

Device: Transcranial Magnetic Stimulation

Interventions

Transcranial Magnetic Stimulation DEVICE

A non-invasive method for brain stimulation

Healthy Control Subjects; Patients

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosed obsessive compulsive disorder
• Not currently receiving cognitive behavioural therapy
• Not currently on any medication or only taking one selective serotonin reuptake inhibitor (SSRI)

You may not qualify if:

• History of psychotic episodes
• History of neurological illness
• Previous head injury
• Active alcohol or substance abuse
• History of seizure disorders
• Currently pregnant

Sponsors & Collaborators

• University of Manitoba: lead

Related Publications (1)

• Modirrousta M, Meek BP, Sareen J, Enns MW. Impaired trial-by-trial adjustment of cognitive control in obsessive compulsive disorder improves after deep repetitive transcranial magnetic stimulation. BMC Neurosci. 2015 Oct 9;16:63. doi: 10.1186/s12868-015-0205-z.

  PMID: 26453446 DERIVED

MeSH Terms

Conditions

Obsessive-Compulsive Disorder

Interventions

Transcranial Magnetic Stimulation

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Magnetic Field Therapy; Therapeutics

Results Point of Contact

• Title: Dr. Mandana Modirrousta
• Organization: University of Manitoba

mmodirrousta@sbgh.mb.ca

2042372303

Study Officials

• Mandana Modirrousta, MD PhD FRCPC

  University of Manitoba

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 2, 2015
• First Posted: September 4, 2015
• Study Start: July 1, 2011
• Primary Completion: June 1, 2015
• Study Completion: June 1, 2015
• Last Updated: September 17, 2020
• Results First Posted: August 27, 2020

Record last verified: 2015-08