Clinical Outcomes in Pediatric Obsessive-Compulsive Disorder
Clinical Outcomes Following Group-based Family Cognitive-Behaviour Therapy in Pediatric Obsessive-Compulsive Disorder (OCD)
1 other identifier
interventional
180
1 country
1
Brief Summary
Obsessive-Compulsive Disorder (OCD) is a common neuropsychiatric illness beginning in childhood. Effective OCD treatments include cognitive-behaviour therapy (CBT) and medications but access to treatment is difficult and does not systematically include parents. The investigators will evaluate clinical and neural effects of Group-based Family CBT (GF-CBT), via a case-control study including: Group 1 - OCD cases receiving GF-CBT (N=90); Group 2 - OCD waitlist cases (N=90). Effects will be measured between baseline and completion of 12 GF-CBT sessions: comparing OCD severity and functioning changes between Groups 1 and 2.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Oct 2012
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 27, 2012
CompletedFirst Posted
Study publicly available on registry
July 9, 2012
CompletedStudy Start
First participant enrolled
October 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
June 1, 2027
May 12, 2023
May 1, 2023
14.7 years
June 27, 2012
May 10, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Children's Yale Brown Obsessive-Compulsive Scale (CY-BOCS)
CY-BOCS: gold-standard measure of OCD severity in pediatric OCD.
Baseline, midpoint, completion of 12 GF-CBT sessions, one-month follow-up
Study Arms (2)
OCD-affected subjects (Group 1)
ACTIVE COMPARATOROCD-affected subjects will participate in 12 sessions of group therapy (as per GF-CBT protocol).
OCD-affected subjects (Group 2)
ACTIVE COMPARATORWaitlist affected-controls awaiting a treatment spot.
Interventions
Baseline and post-12 sessions
Eligibility Criteria
You may qualify if:
- Male or female, aged 5-18 years old
- Ability of subject and parent to provide informed assent/consent
- English-speaking
- Current DSM IV-TR Axis I diagnosis of childhood-onset OCD; Moderate to severe OCD (CY-BOCS≥16/40)
You may not qualify if:
- Current diagnosis of bipolar disorder, psychosis, mental retardation or pervasive developmental disorder (e.g., autism), and current or past substance dependence/abuse
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
BC Children's Hospital Research Institute
Vancouver, British Columbia, Canada
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
S. Evelyn Stewart, MD
University of British Columbia
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principle Investigator
Study Record Dates
First Submitted
June 27, 2012
First Posted
July 9, 2012
Study Start
October 1, 2012
Primary Completion (Estimated)
June 1, 2027
Study Completion (Estimated)
June 1, 2027
Last Updated
May 12, 2023
Record last verified: 2023-05