Dietary Arachidonic Acid, Obesity and Atopic Respiratory Disease

NCT02525354 | Completed

• 1 other identifier: UNH-01-2536-01
• Study Type: observational
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

Epidemiological studies have shown obesity to be a risk factor of asthma. Research evidence of obesity and atopic(ie. allergic)-related respiratory diseases, has been less clear. The purpose of the present study was to test the hypothesis that the relationship between obesity and atopic-related respiratory disease in premenopausal women is mediated by a dietary imbalance of omega 6 and 3 polyunsaturated fatty acids.

Conditions

Allergy; Obesity

Keywords

arachidonic aci; adiposity; atopy

Outcome Measures

Primary Outcomes (1)

• Predictors of serum concentration of specific and total IgE antibodies in obesity

  Measures of insulin sensitivity, plasma concentrations of leptin, adiponectin, , estrogen, IL-18,and dietary arachidonic, eicosapentanoic, docosahexanoic fatty acids were entered as independent variables; and serum concentration of specific and total IgE antibodies as dependent variable, in a forward stepwise multivariate linear regression analysis to identify which factor(s) had the greatest influence on serum concentrations of IgE antibodies in obesity.

  one day

Secondary Outcomes (2)

• Relationship between dietary levels of arachidonic, eicosapentanoic, docosahexanoic fatty acids and plasma concentration of leptin in obesity

  one day

• Correlation between dietary arachidonic, eicosapentanoic,and docoshexanoic fatty acids and plasma concentration of adiponectin in obesity

  one day

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Female subjects were recruited from the University and surrounding local communities, using posted flyers, website announcements, personal announcements in classes, referrals from local physicians, and word of mouth. Prospective subjects were interviewed initially by telephone.

You may qualify if:

• For asthmatics, only individuals that were willing and capable of not using asthma medications for two days prior to laboratory testing.

You may not qualify if:

• An individual was excluded from the study if she had a history of high blood pressure, diabetes, heart disease, cigarette smoking, or eating disorders.
• Women that were pregnant or lactating.

Sponsors & Collaborators

• University of New Hampshire: lead

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Biospecimen

Retention: SAMPLES WITHOUT DNA

plasma samples

MeSH Terms

Conditions

Hypersensitivity; Obesity

Condition Hierarchy (Ancestors)

Immune System Diseases; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Human Nutrition

Study Record Dates

• First Submitted: June 15, 2015
• First Posted: August 17, 2015
• Study Start: October 1, 2001
• Primary Completion: May 1, 2003
• Study Completion: May 1, 2003
• Last Updated: August 17, 2015

Record last verified: 2015-07