Influence of Emotional Disorders and Executive on the Components Retrograde and Anterograde Episodic Memory in MS

NCT02518776 | Unknown

• 1 other identifier: 09-016
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system responsible for physical disability but can also cause cognitive disturbances annoying social and professional life of patients with the disease. Various studies have shown that there was a breach of episodic memory, working memory, attention and executive functions regardless of the form of disease, disability or duration of disease progression. The main objective of this study is to investigate the influence of emotional components and executive processes on the components retrograde and anterograde episodic memory (thanks to an original paradigm based on the emotional valence of the memory) in MS patients

Conditions

Multiple Sclerosis

Outcome Measures

Primary Outcomes (2)

• anterograde episodic memory: 3 scores of emotional ESR

  3 scores of emotional ESR

  baseline

• retrograde episodic memory: 9 scores TEMP emotional

  9 scores TEMP emotional

  baseline

Study Arms (1)

Neuropsychological tests

OTHER

Behavioral: Neuropsychological tests

Interventions

Neuropsychological tests BEHAVIORAL

Neuropsychological tests

Neuropsychological tests

Eligibility Criteria

• Age: 30 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Men and women 30-60 years of age
• Definite MS (McDonald criteria revised in 2005)
• EDSS \<6
• Sick Shapes: Relapsing multiple sclerosis, Primary progressive multiple sclerosis
• All durations evolution
• French Mother tongue
• Signature of informed consent

You may not qualify if:

• Other neurological conditions, previous psychiatric or developmental diagnosis of MS
• Head injury sequelae
• Chronic alcohol or drugs Taking
• EDSS greater than or equal to 6
• Secondary Progressive Form
• Push and / or treatment with corticosteroids within one month
• Treatments Amantadine, Modafinil introduced for less than 3 months
• Patient Trust
• Cognitive Assessment of less than one year (including in particular all or part of the balance sheet proposed in this project)
• Any visual motor deficit or incompatible with the award of cognitive tests
• For women, pregnancy, breastfeeding and / or lack of contraception (a pregnancy test will be done before the PET scan)
• Patient with indications against MRI

Sponsors & Collaborators

• University Hospital, Caen: lead

Study Sites (1)

Department of Neurologie, Caen Hospital University

Caen, Basse-Normandie, 14033, France

RECRUITING

MeSH Terms

Conditions

Multiple Sclerosis

Interventions

Neuropsychological Tests

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Psychological Tests; Behavioral Disciplines and Activities

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 6, 2015
• First Posted: August 10, 2015
• Study Start: June 1, 2010
• Primary Completion: July 1, 2016
• Last Updated: August 10, 2015

Record last verified: 2015-08

Locations

FR (1)