Wine Consumption and Glycemic Control
WGC
1 other identifier
interventional
14
1 country
1
Brief Summary
Many studies have reported that alcoholic beverage consumption, especially in the form of wine, reduces the risk of developing type 2 diabetes by as much as 40%. This association suggests that wine consumption may somehow improve the body's ability to control its blood glucose concentration. Indeed, it has been reported that when wine is consumed immediately prior to ingestion of glucose, the release of insulin is enhanced and blood glucose concentration is lowered. The mechanism of wine's effects on blood glucose concentration is unknown, but is likely related to its ethanol or antioxidant content. In this study, the investigators plan to test whether wine or plain ethanol (vodka) ingestion alters the control of blood glucose in subjects who have diabetes or pre-diabetes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable diabetes-mellitus-type-2
Started Mar 2012
Longer than P75 for not_applicable diabetes-mellitus-type-2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 8, 2012
CompletedStudy Start
First participant enrolled
March 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2015
CompletedFirst Posted
Study publicly available on registry
August 7, 2015
CompletedOctober 26, 2017
October 1, 2017
3 years
February 8, 2012
October 24, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Oral glucose tolerance test
Measurement of blood glucose taken every 15 minutes over a course of three hours.
3 weeks
Study Arms (1)
Alcohol consumption
EXPERIMENTALAlcohol consumption and wine consumption
Interventions
28 grams (2 drinks) of ethanol will be consumed either in the form of wine or vodka.
Eligibility Criteria
You may qualify if:
- insulin resistant: diagnosed with pre-diabetes or fasting blood glucose \>/= 97 mg/dL
- T2D: diagnosed by primary care physician
- at risk of type 2 diabetes (obesity and physically inactive)
- age: 21-65
You may not qualify if:
- smoking
- insulin use (other than once daily)
- physically active (\>30 mins aerobic exercise two days/week)
- recent (\>3 mo) changes in medication use or dose
- uncontrolled type two diabetes (HbA1C \>10%)
- advanced retinopathy or neuropathy
- pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Missouri
Columbia, Missouri, 65202, United States
Related Publications (1)
Avogaro A, Watanabe RM, Dall'Arche A, De Kreutzenberg SV, Tiengo A, Pacini G. Acute alcohol consumption improves insulin action without affecting insulin secretion in type 2 diabetic subjects. Diabetes Care. 2004 Jun;27(6):1369-74. doi: 10.2337/diacare.27.6.1369.
PMID: 15161790BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
John P Thyfault, PhD
University of Missouri-Columbia
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 8, 2012
First Posted
August 7, 2015
Study Start
March 1, 2012
Primary Completion
March 1, 2015
Study Completion
March 1, 2015
Last Updated
October 26, 2017
Record last verified: 2017-10
Data Sharing
- IPD Sharing
- Will not share