Improving the Detection of Active Tuberculosis in Accident and Emergency Departments
ACE
1 other identifier
observational
1,000
1 country
3
Brief Summary
Tuberculosis (TB) control remains a public health challenge. Many people in the UK do not have a general practitioner (GP) registration and their only interaction with the NHS is via Accident and Emergency (A\&E) Departments of hospitals. This is often the case for those in hard to reach groups, who are also those often at highest risk of TB. This study seeks to assess whether A\&E Departments are effective sites for the identification and onward management of TB, both in its latent and active forms.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2016
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 27, 2015
CompletedFirst Posted
Study publicly available on registry
July 31, 2015
CompletedStudy Start
First participant enrolled
May 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2017
CompletedMarch 16, 2016
March 1, 2016
1 year
July 27, 2015
March 15, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
xray diagnosis of active TB
clinical signs and symptoms on xray
1 year
Secondary Outcomes (1)
diagnosis of latent TB
1 year
Study Arms (1)
high risk TB individuals attending A&E Departments
Assessment against inclusion/exclusion criteria in terms of risk of TB. If eligible, assessment and testing as appropriate for active or latent TB
Interventions
venepuncture, sputum collection, xray
Eligibility Criteria
Individuals at high risk of TB
You may qualify if:
- Individuals 16 years or older, who are new entrants from high incidence countries who have arrived in the UK within the past 2 years or those born in high incidence countries who entered the UK more than five years ago, but have spent more than one year (cumulative) in the past five years in a high incidence country.
- Those with social risk factors who have signs and/or symptoms of TB.
You may not qualify if:
- Individuals who are under 16 years
- Individuals who were born in the UK or a low incidence countries and do not have risk factors
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Barts NHS Trust
London, London, Ha73qx, United Kingdom
Ealing Hospital
London, London, NW95EQ, United Kingdom
West Middlesex Hospital NHS Trust
London, London, United Kingdom
Related Publications (1)
Gupta RK, Lule SA, Krutikov M, Gosce L, Green N, Southern J, Imran A, Aldridge RW, Kunst H, Lipman M, Lynn W, Burgess H, Rahman A, Menezes D, Rahman A, Tiberi S, White PJ, Abubakar I. Screening for tuberculosis among high-risk groups attending London emergency departments: a prospective observational study. Eur Respir J. 2021 Jun 24;57(6):2003831. doi: 10.1183/13993003.03831-2020. Print 2021 Jun.
PMID: 33737408DERIVED
Biospecimen
Retention of residual blood samples after inital testing, with appropriate consent to do so from individuals and ethics committee.
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Clinical Research Lead
Study Record Dates
First Submitted
July 27, 2015
First Posted
July 31, 2015
Study Start
May 1, 2016
Primary Completion
May 1, 2017
Study Completion
December 1, 2017
Last Updated
March 16, 2016
Record last verified: 2016-03