Effects of Yoga on Parkinson's Disease
HYPD
Effects of Yoga on Redox Status, Motor Function and Psychosocial Well-being in Individuals With Parkinson's Disease
1 other identifier
interventional
20
1 country
1
Brief Summary
The study's purpose is to assess the effect of yoga on measures of oxidative stress (i.e. reduction-oxidation \[redox\] status); motor function; and psychosocial well-being, and the feasibility and acceptability of implementing a Hatha yoga program in PD subjects.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 2015
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 20, 2015
CompletedFirst Posted
Study publicly available on registry
July 28, 2015
CompletedStudy Start
First participant enrolled
August 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2017
CompletedMay 31, 2018
June 1, 2017
1.3 years
July 20, 2015
May 30, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Redox status
The antioxidant glutathione (GSH) and the GSH: glutathione disulfide (GSSG) ratio will be measured at baseline and at the end of the program.
12 weeks
Secondary Outcomes (8)
Motor function
12 weeks
Motor function
12 weeks
Motor function
12 weeks
Cognitive function
12 weeks
Mood
12 weeks
- +3 more secondary outcomes
Other Outcomes (3)
Yoga feasibility
Baseline and 12 weeks
Yoga acceptability
12 weeks
Yoga program fidelity
4 weeks, 8 weeks, and 12 weeks
Study Arms (2)
Immediate treatment
EXPERIMENTALParticipants who are randomly assigned to the immediate treatment group will receive 60-minute biweekly Hatha yoga for 12 weeks.
Waitlist control
ACTIVE COMPARATORParticipants who are randomly assigned to the wait-list group will receive no intervention during the first 12 weeks. Not only will they serve as the comparative group, they will also serve as their own control and receive the same yoga intervention at the end of 12 weeks when the immediate treatment group completed their program.
Interventions
Yoga programs that were used in previous PD studies will be incorporated into the design of the proposed intervention program. Two yoga experts who are specialized in musculoskeletal/neurological disorders will review the program. The yoga intervention classes will be taught by a Registered Yoga Teacher. The 60 minute long yoga session will be held twice a week for 12 weeks at a community center in St. Louis Park.
Eligibility Criteria
You may qualify if:
- Individuals diagnosed with idiopathic PD;
- On optimized dopaminergic therapy for 4 weeks prior to enrollment; and
- Have not practiced any form of yoga regularly (more than 2 days a week) in the past 6 months; and
- Not currently participating in a supervised exercise program more than 2 days a week
You may not qualify if:
- Atypical Parkinsonism or other significant brain conditions such as a stroke;
- Fell more than once in the past 3 months;
- Moderate to severe cognitive impairment (scored \<26) as indicated by the Montreal Cognitive Assessment;
- Decline in immune function such as pneumonia or systemic infection;
- Spinal fusion or other orthopedic surgery in the past 6 months;
- Unstable cardiovascular conditions;
- Significant mental disease or psychosis;
- Not able to ambulate 6 meters steadily without assistive device.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Minnesota
Minneapolis, Minnesota, 55455, United States
Related Publications (2)
Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3.
PMID: 38588457DERIVEDErnst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2.
PMID: 36602886DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Corjena Cheung, PhD
University of Minnesota
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 20, 2015
First Posted
July 28, 2015
Study Start
August 1, 2015
Primary Completion
December 1, 2016
Study Completion
June 1, 2017
Last Updated
May 31, 2018
Record last verified: 2017-06
Data Sharing
- IPD Sharing
- Will not share