The Influence of Oxytocin on Pair-bonding and Emotion Regulation
1 other identifier
interventional
40
1 country
1
Brief Summary
The neuropeptide oxytocin (OXT) has been identified as a key modulator of human social behavior and it has been recently shown that OXT also contributes to pair-bonding in men. However, it is still elusive whether OXT has similar effects in women. In the present study, the investigators examine the effect of intranasal OXT on behavioral ratings of and neural responses to the male partner in female participants. In a second experiment, the modulatory effect of OXT on emotion regulation is investigated.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for early_phase_1 healthy
Started Jul 2014
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2015
CompletedFirst Submitted
Initial submission to the registry
July 15, 2015
CompletedFirst Posted
Study publicly available on registry
July 17, 2015
CompletedJuly 17, 2015
July 1, 2015
11 months
July 15, 2015
July 15, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Neural response to photographs of the partner
Neural responses will be measured by using functional magnetic resonance imaging (fMRI). In the fMRI analysis the effect of oxytocin on the neural response to the photograph of the partner will be compared with placebo.
About one hour after the intranasal administration of oxytocin
Neural response during the regulation of food craving
Neural responses will be measured by using functional magnetic resonance imaging (fMRI). In the fMRI analysis the effect of oxytocin on the neural response to the regulation of food craving will be compared with placebo.
About one hour after the intranasal administration of oxytocin
Secondary Outcomes (3)
Attractiveness ratings of all stimuli
About one hour after the intranasal administration of oxytocin
Arousal ratings of all stimuli
About one hour after the intranasal administration of oxytocin
Food craving ratings
About one hour after the intranasal administration of oxytocin
Study Arms (2)
Oxytocin
EXPERIMENTAL24 IU Oxytocin (Syntocinon spray), intranasal application 30 min prior to the experiment
Placebo
PLACEBO COMPARATORIntranasal application, containing all ingredients except for the peptide, 3 puffs per nostril
Interventions
Eligibility Criteria
You may qualify if:
- Healthy female volunteers
- In a heterosexual relationship
You may not qualify if:
- Current or past psychiatric disease
- Current or past physical illness
- Psychoactive medication
- Pregnant or lactating
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Psychiatry, University of Bonn
Bonn, 53105, Germany
Related Links
Study Design
- Study Type
- interventional
- Phase
- early phase 1
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Antragsteller und verantwortlicher Leiter
Study Record Dates
First Submitted
July 15, 2015
First Posted
July 17, 2015
Study Start
July 1, 2014
Primary Completion
June 1, 2015
Study Completion
June 1, 2015
Last Updated
July 17, 2015
Record last verified: 2015-07