Physical Functioning Throughout Lung Cancer Treatment

NCT02493114 | Completed

• 1 other identifier: 1
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This trial investigates the impact of lung cancer treatment on physical status, symptoms and quality of life. Furthermore this trial investigates possible underlying causes and consequences of deconditioning.

Conditions

Lung Cancer; Exercise Capacity; Physical Activity; Quality of Life

Outcome Measures

Primary Outcomes (3)

• 6MWT

  Before start of treatment versus 3 months after treatment initiation

• 1-minute sit to stand test

  Before start of treatment versus 3 months after treatment initiation

• SPPB

  Before start of treatment versus 3 months after treatment initiation

Secondary Outcomes (4)

• Handgrip strength

  Before start of treatment vs. 3 months after treatment initiation

• Daily physical activity (self-reported and accelerometer)

  Before start of treatment vs. during treatment (surgery: during hospitalization; radio: week 2; chemo: beginning of cycle 2 and cycle 4 (each cycle is 3 weeks); immuno: beginning of cycle 2 and cycle 4) vs. 3 months after treatment initiation

• Quadriceps strength (isometric and isokinetic)

  Before start of treatment vs. 3 months after treatment initiation

• Respiratory muscle strength (maximal inspiratory and expiratory pressure)

  Before start of treatment vs. 3 months after treatment initiation

Other Outcomes (14)

• Comorbidities

  Before start of treatment

• Number of hospital admissions

  12 months after treatment initiation

• All cause and cancer-related mortality

  12 months after treatment initiation

Study Arms (2)

Patients with lung cancer

No study intervention

Healthy controls

No study intervention

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients with a primary diagnosis of non-small-cell lung cancer who will undergo treatment (surgery, chemotherapy, immunotherapy, radiotherapy, and combination of the previous ones) and score a maximal of 2 on the WHO performance status classification, will be eligible for inclusion. Healthy matched volunteers will carry out the same assessments once.

You may qualify if:

• undergoing treatment (surgery, chemotherapy, immunotherapy, radiotherapy, and combination of the previous ones)
• WHO performance status of maximal 2

You may not qualify if:

• presence of other neoplasms in the last 2 years
• bone metastasis
• progressive neuromuscular and neurological diseases
• unstable cardiac disease
• pulmonary hypertension
• interstitial lung disease
• orthopedic conditions that significantly impair functional status
• mental or psychiatric disorders that impair the ability to comply with study procedures.
• a history of cerebrovascular accident with remaining functional consequences
• a history of lung cancer
• difficulties in understanding and speaking Dutch

Sponsors & Collaborators

• Hasselt University: lead

Study Sites (1)

Ziekenhuis Oost-Limburg

Genk, 3600, Belgium

Location

Related Publications (1)

• Quadflieg K, Arents E, Haesevoets S, Van Hulle F, Hermans F, Criel M, Daenen M, Derom E, Spruit MA, Surmont V, Stevens D, Ruttens D, Demeyer H, Burtin C. Impact of cancer treatment on physical functioning, symptoms and health-related quality of life in patients with non-small cell lung cancer: A longitudinal observational study. Respir Med. 2025 Oct;247:108283. doi: 10.1016/j.rmed.2025.108283. Epub 2025 Jul 31.

  PMID: 40752628 DERIVED

MeSH Terms

Conditions

Lung Neoplasms; Motor Activity

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: June 11, 2015
• First Posted: July 9, 2015
• Study Start: July 1, 2015
• Primary Completion: October 31, 2024
• Study Completion: October 31, 2024
• Last Updated: September 15, 2025

Record last verified: 2025-09

Locations

BE (1)