Collection and Storage of Tissue and Blood Samples From Patients With Cancer

NCT02474160 | Recruiting

• 10 other identifiers: NCI-2015-00863P9846P9846_R02PAPPHOLD019846UM1CA186689UM1CA186691UM1CA186704UM1CA186709UM1CA186717ZIABC011078
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 140

Brief Summary

This study collects and stores tissue and blood samples from patients with cancer. Collecting and storing samples of tissue and blood from patients with cancer to study in the laboratory may help scientists create new and better models to learn about cancer and to test new cancer drugs.

Conditions

Hematopoietic and Lymphatic System Neoplasm; Malignant Solid Neoplasm; Metastatic Malignant Solid Neoplasm; Recurrent Malignant Solid Neoplasm

Outcome Measures

Primary Outcomes (1)

• Procurement of tissue and blood specimens for research purposes

  Tissues and venous blood will be stored, implanted immediately to generate patient-derived xenografts (which require fresh, viable cells), or placed immediately into in vitro cell culture to generate patient-derived cell lines (which require fresh, viable cells).

  Up to 5 years

Study Arms (1)

Observational (tissue and blood procurement)

Tumor tissue and blood samples are procured during procedures that are required for the patients' clinical management and stored via xenograft (transplant to another species) models or in vitro cell culture for future analysis.

Other: Cytology Specimen Collection Procedure

Interventions

Cytology Specimen Collection Procedure OTHER

Procurement of tissue and blood samples

Also known as: Cytologic Sampling

Observational (tissue and blood procurement)

Eligibility Criteria

• Age: 2 Months+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing evaluation and/or treatment for cancer

You may qualify if:

• Patients older than 2 months of age who are being evaluated, treated, or enrolled in a clinical trial for cancer at participating sites
• Patients with a histologically or cytologically confirmed diagnosis of cancer
• Patients without histologically or cytologically confirmed diagnosis of cancer, but for whom approval has been requested and received from the coordinating site study coordinator
• Requests for coordinating site approval should only be made if the patient's existing work-up at the time of the request demonstrates a combination of two or more of the following indicating the greater likelihood of a cancerous process in the assessment of the treating physician:
• Radiographic imaging (computed tomography \[CT\], magnetic resonance imaging \[MRI\], etc.)
• Elevated tumor markers
• Clinical symptoms
• Documented risk factors, known genetic changes (mutation, deletion, fusion, etc.), and/or known familial cancer history or syndrome
• Complete blood count (CBC) w/differential indicative of a probable hematologic malignancy
• If the patient will be undergoing surgical resection at a later time and will be accessible to approach for study participation at that time, resected material following cancer diagnosis confirmation is preferred
• Important: Additional medical, genetic and/or demographic work-up should not be obtained solely for determination of eligibility for protocol 9846 by these criteria. Once available, final histology must be confirmed to the coordinating site detailing the cancer diagnosis for patients enrolled based on the above criteria
• Patients with a newly diagnosed primary and/or metastatic solid tumor or hematologic malignancy for which they have not yet received treatment
• Patients with a solid tumor or hematologic malignancy that is recurrent, newly metastasized, or progressing while on treatment indicated by:
• Radiographic evidence of tumor growth, re-growth, and/or new metastases, OR
• Documentation by the treating physician of clinical disease progression, OR

You may not qualify if:

• Patients with cancer-like syndromes and/or blood disorders such as systemic mastocytosis, Langerhans cell histiocytosis, chronic eosinophilic leukemia/hypereosinophilic syndrome, lymphomatoid granulomatosis, or monoclonal gammopathy of undetermined significance (MGUS)
• Patients with invasive fungal infections
• Patients with active and/or uncontrolled bacterial, fungal, or viral infections or who are still recovering from an infection
• Actively febrile patients with uncertain etiology of febrile episode
• All antibiotics prescribed for the treatment of a bacterial infection should be completed at least 1 week (7 days) prior to collection
• Patients with a hematologic malignancy who are treated with an antibiotic, anti-fungal, and/or anti-viral medication for an active infection who then remain on the treatment for prophylaxis following resolution of the infection as assessed by the treating physician are not excluded
• No recurrence of fever or other symptoms related to infection for at least 1 week (7 days) following completion of antibiotics
• Patients receiving antibiotics, antifungals, and/or antivirals for prophylaxis are permissible
• Antibiotics being administered topically at a location distant from the planned tissue collection site or eye drops for a localized infection are permissible
• Patients with human immunodeficiency virus (HIV), active or chronic hepatitis (i.e., quantifiable hepatitis B virus \[HBV\]-deoxyribonucleic acid \[DNA\] and/or positive hepatitis B surface antigen \[HbsAg\], quantifiable hepatitis C virus \[HCV\]-ribonucleic acid \[RNA\]) or known history of HCV, HBV, or HIV; testing for HBV, HCV, HIV or other infections for eligibility will be performed only if clinically indicated
• Patients with hepatitis A as indicated by anti-hepatitis A virus (HAV) IgM reactivity
• Patients that are anti-HAV IgG reactive only are eligible
• Specimen collections from patients with benign tumors including but not limited to desmoid tumors, carcinoma in situ, or ongoing evidence of complete disease response (CR)

Sponsors & Collaborators

• National Cancer Institute LAO: lead
• National Cancer Institute (NCI): collaborator

Study Sites (140)

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States

SUSPENDED

Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States

RECRUITING

PCR Oncology

Arroyo Grande, California, 93420, United States

ACTIVE NOT RECRUITING

City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States

ACTIVE NOT RECRUITING

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States

ACTIVE NOT RECRUITING

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States

ACTIVE NOT RECRUITING

Smilow Cancer Center/Yale-New Haven Hospital

New Haven, Connecticut, 06510, United States

ACTIVE NOT RECRUITING

Yale University

New Haven, Connecticut, 06520, United States

ACTIVE NOT RECRUITING

Delaware Clinical and Laboratory Physicians PA

Newark, Delaware, 19713, United States

ACTIVE NOT RECRUITING

Helen F Graham Cancer Center

Newark, Delaware, 19713, United States

ACTIVE NOT RECRUITING

Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713, United States

ACTIVE NOT RECRUITING

Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States

ACTIVE NOT RECRUITING

Christiana Care Health System-Wilmington Hospital

Wilmington, Delaware, 19801, United States

ACTIVE NOT RECRUITING

Augusta University Medical Center

Augusta, Georgia, 30912, United States

RECRUITING

OSF Saint Joseph Medical Center

Bloomington, Illinois, 61701, United States

ACTIVE NOT RECRUITING

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States

SUSPENDED

Illinois CancerCare-Canton

Canton, Illinois, 61520, United States

SUSPENDED

Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States

SUSPENDED

Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States

SUSPENDED

Centralia Oncology Clinic

Centralia, Illinois, 62801, United States

SUSPENDED

John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States

RECRUITING

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States

RECRUITING

Decatur Memorial Hospital

Decatur, Illinois, 62526, United States

RECRUITING

Crossroads Cancer Center

Effingham, Illinois, 62401, United States

SUSPENDED

Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States

SUSPENDED

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States

SUSPENDED

Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States

SUSPENDED

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States

SUSPENDED

Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States

SUSPENDED

SSM Health Good Samaritan

Mount Vernon, Illinois, 62864, United States

RECRUITING

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States

SUSPENDED

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States

SUSPENDED

Radiation Oncology of Northern Illinois

Ottawa, Illinois, 61350, United States

SUSPENDED

Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States

SUSPENDED

OSF Saint Francis Radiation Oncology at Pekin

Pekin, Illinois, 61554, United States

SUSPENDED

Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States

SUSPENDED

OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, 61615, United States

SUSPENDED

Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States

SUSPENDED

OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States

SUSPENDED

Illinois CancerCare-Peru

Peru, Illinois, 61354, United States

SUSPENDED

Valley Radiation Oncology

Peru, Illinois, 61354, United States

SUSPENDED

Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States

SUSPENDED

Central Illinois Hematology Oncology Center

Springfield, Illinois, 62702, United States

ACTIVE NOT RECRUITING

Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States

SUSPENDED

Springfield Clinic

Springfield, Illinois, 62702, United States

SUSPENDED

Springfield Memorial Hospital

Springfield, Illinois, 62781, United States

SUSPENDED

Cancer Center of Kansas - Chanute

Chanute, Kansas, 66720, United States

SUSPENDED

Cancer Center of Kansas - Dodge City

Dodge City, Kansas, 67801, United States

SUSPENDED

Cancer Center of Kansas - El Dorado

El Dorado, Kansas, 67042, United States

SUSPENDED

Cancer Center of Kansas - Fort Scott

Fort Scott, Kansas, 66701, United States

SUSPENDED

Cancer Center of Kansas-Independence

Independence, Kansas, 67301, United States

SUSPENDED

Cancer Center of Kansas-Kingman

Kingman, Kansas, 67068, United States

SUSPENDED

Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States

SUSPENDED

Cancer Center of Kansas-Liberal

Liberal, Kansas, 67905, United States

SUSPENDED

Cancer Center of Kansas-Manhattan

Manhattan, Kansas, 66502, United States

SUSPENDED

Cancer Center of Kansas - Newton

Newton, Kansas, 67114, United States

SUSPENDED

Cancer Center of Kansas - Parsons

Parsons, Kansas, 67357, United States

SUSPENDED

Cancer Center of Kansas - Pratt

Pratt, Kansas, 67124, United States

SUSPENDED

Cancer Center of Kansas - Salina

Salina, Kansas, 67401, United States

SUSPENDED

Cancer Center of Kansas - Wellington

Wellington, Kansas, 67152, United States

SUSPENDED

Associates In Womens Health

Wichita, Kansas, 67208, United States

SUSPENDED

Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States

SUSPENDED

Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States

RECRUITING

Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214, United States

RECRUITING

Wesley Medical Center

Wichita, Kansas, 67214, United States

SUSPENDED

Cancer Center of Kansas - Winfield

Winfield, Kansas, 67156, United States

SUSPENDED

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States

ACTIVE NOT RECRUITING

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States

ACTIVE NOT RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States

ACTIVE NOT RECRUITING

Bronson Battle Creek

Battle Creek, Michigan, 49017, United States

SUSPENDED

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States

RECRUITING

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States

SUSPENDED

West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States

SUSPENDED

Ascension Borgess Hospital

Kalamazoo, Michigan, 49048, United States

SUSPENDED

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States

ACTIVE NOT RECRUITING

Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States

SUSPENDED

Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States

SUSPENDED

Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States

SUSPENDED

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States

SUSPENDED

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States

SUSPENDED

Munson Medical Center

Traverse City, Michigan, 49684, United States

SUSPENDED

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

ACTIVE NOT RECRUITING

Baptist Memorial Hospital and Cancer Center-Oxford

Oxford, Mississippi, 38655, United States

RECRUITING

Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States

SUSPENDED

Parkland Health Center-Bonne Terre

Bonne Terre, Missouri, 63628, United States

SUSPENDED

Cox Cancer Center Branson

Branson, Missouri, 65616, United States

SUSPENDED

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States

SUSPENDED

Southeast Cancer Center

Cape Girardeau, Missouri, 63703, United States

SUSPENDED

MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States

SUSPENDED

Freeman Health System

Joplin, Missouri, 64804, United States

RECRUITING

Mercy Hospital Joplin

Joplin, Missouri, 64804, United States

RECRUITING

Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401, United States

RECRUITING

Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States

SUSPENDED

Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States

RECRUITING

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States

SUSPENDED

Mercy Hospital Springfield

Springfield, Missouri, 65804, United States

RECRUITING

CoxHealth South Hospital

Springfield, Missouri, 65807, United States

RECRUITING

Saint Louis Cancer and Breast Institute-South City

St Louis, Missouri, 63109, United States

SUSPENDED

Washington University School of Medicine

St Louis, Missouri, 63110, United States

ACTIVE NOT RECRUITING

Mercy Hospital South

St Louis, Missouri, 63128, United States

RECRUITING

Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States

RECRUITING

Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States

RECRUITING

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States

SUSPENDED

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127, United States

SUSPENDED

Cancer and Blood Specialists-Henderson

Henderson, Nevada, 89052, United States

ACTIVE NOT RECRUITING

Cancer and Blood Specialists-Shadow

Las Vegas, Nevada, 89106, United States

ACTIVE NOT RECRUITING

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

Las Vegas, Nevada, 89109, United States

ACTIVE NOT RECRUITING

HealthCare Partners Medical Group Oncology/Hematology-San Martin

Las Vegas, Nevada, 89113, United States

ACTIVE NOT RECRUITING

Cancer Therapy and Integrative Medicine

Las Vegas, Nevada, 89121, United States

ACTIVE NOT RECRUITING

Cancer and Blood Specialists-Tenaya

Las Vegas, Nevada, 89128, United States

ACTIVE NOT RECRUITING

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

Las Vegas, Nevada, 89128, United States

ACTIVE NOT RECRUITING

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148, United States

ACTIVE NOT RECRUITING

OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89148, United States

ACTIVE NOT RECRUITING

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

Las Vegas, Nevada, 89149, United States

ACTIVE NOT RECRUITING

Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169, United States

ACTIVE NOT RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States

RECRUITING

Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States

ACTIVE NOT RECRUITING

Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States

ACTIVE NOT RECRUITING

Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States

ACTIVE NOT RECRUITING

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States

SUSPENDED

Duke University Medical Center

Durham, North Carolina, 27710, United States

ACTIVE NOT RECRUITING

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States

RECRUITING

Baptist Memorial Hospital and Cancer Center-Memphis

Memphis, Tennessee, 38120, United States

RECRUITING

M D Anderson Cancer Center

Houston, Texas, 77030, United States

ACTIVE NOT RECRUITING

MultiCare Auburn Medical Center

Auburn, Washington, 98001, United States

ACTIVE NOT RECRUITING

Virginia Mason Bainbridge Island Medical Center

Bainbridge Island, Washington, 98110, United States

ACTIVE NOT RECRUITING

Virginia Mason Federal Way Medical Center

Federal Way, Washington, 98002, United States

ACTIVE NOT RECRUITING

MultiCare Gig Harbor Medical Park

Gig Harbor, Washington, 98335, United States

ACTIVE NOT RECRUITING

Virginia Mason Lynnwood Medical Center

Lynnwood, Washington, 98036, United States

ACTIVE NOT RECRUITING

MultiCare Good Samaritan Hospital

Puyallup, Washington, 98372, United States

ACTIVE NOT RECRUITING

Virginia Mason Medical Center

Seattle, Washington, 98101, United States

ACTIVE NOT RECRUITING

Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729, United States

ACTIVE NOT RECRUITING

Marshfield Clinic Cancer Center at Sacred Heart

Eau Claire, Wisconsin, 54701, United States

ACTIVE NOT RECRUITING

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States

SUSPENDED

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States

ACTIVE NOT RECRUITING

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States

ACTIVE NOT RECRUITING

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States

ACTIVE NOT RECRUITING

Aspirus Cancer Care - Stevens Point

Stevens Point, Wisconsin, 54481, United States

ACTIVE NOT RECRUITING

Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States

ACTIVE NOT RECRUITING

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States

ACTIVE NOT RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Tissue and blood

MeSH Terms

Conditions

Neoplasm Metastasis

Condition Hierarchy (Ancestors)

Neoplastic Processes; Neoplasms; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• James H Doroshow

  National Cancer Institute (NCI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: UNKNOWN
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 15, 2015
• First Posted: June 17, 2015
• Study Start: May 19, 2015
• Primary Completion: May 4, 2026
• Study Completion: May 4, 2026
• Last Updated: March 5, 2026

Record last verified: 2026-03

Locations

US (140)