Comparative Analysis of APACHE II and P-POSSUM

NCT02471612 | Completed Results DMC

• 1 other identifier: 201-26104-132-108296
• Study Type: observational
• Target: 159
• Locations: 1 country
• Sites: 1

Brief Summary

To compare APACHE II and P-POSSUM scoring system in emergency laparotomy.

Conditions

External Causes of Morbidity and Mortality

Outcome Measures

Primary Outcomes (1)

• Area Under the Receiver Operating Curve (ROC) as a Measure of the Accuracy of the APACHE II and P-POSSUM Scoring Systems to Predict Mortality

  Participants will be followed for the duration of hospital stay (expected average of 30 days) and mortality was noted.All patients undergoing emergency laparotomy at Tata Main Hospital form 01st December 2013 to 30th November 2014 were included in the study. All patients were scored with APACHE II and P-POSSUM scoring systems on the day of surgery. Area under the curve (AUC) is used to measure the "size" of the prediction composed by the graphic display between the 'sensitivity' and the '1-specificity' relationship. AUC can range from 0.5 to 1.0 and a result of 1.0 indicates a perfect discriminatory ability. An AUC value \> 0.8 is considered good, a range between 0.60-0.80 is considered as moderate, and an AUC value \< 0.60 is regarded as poor. For APACHE-II, a cut off score of \>/=24 was determined; for P-POSSUM, a cut off score of \>/= 63 was determined.

  30 days

Secondary Outcomes (6)

• Length of Stay (LOS)

  30 days

• Need for Postoperative Ventilator Support

  30 days

• Need for Post Operative Inotropic Support

  30 days

• Cardiac Morbidity (AMI or Arrhythmias Needing Treatment)

  30 days

• Number of Participants With Acute Kidney Injury (AKI)

  30 days

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients undergoing emergency laparotomy at Tata Main Hospital form 01st December 2013 to 30th November 2014 will be included in the study. All patients will be scored with APACHE II and P-POSSUM scoring systems on the day of surgery.The patients will be followed up till discharge, death or 30 days postoperatively.

You may qualify if:

• All patients above 18 years of age undergoing emergency laparotomy at Tata Main Hospital form 01st December 2013 to 30th November 2014 will be included in the study.

You may not qualify if:

• Patients willingly seeking referral to a different hospital

Sponsors & Collaborators

• Tata Main Hospital: lead

Study Sites (1)

Tata Main Hospital

Jamshedpur, Jharkhand, 831001, India

Location

Related Publications (1)

• Nag DS, Dembla A, Mahanty PR, Kant S, Chatterjee A, Samaddar DP, Chugh P. Comparative analysis of APACHE-II and P-POSSUM scoring systems in predicting postoperative mortality in patients undergoing emergency laparotomy. World J Clin Cases. 2019 Aug 26;7(16):2227-2237. doi: 10.12998/wjcc.v7.i16.2227.

  PMID: 31531317 RESULT

Limitations and Caveats

Observational study. So no specific adverse effect because of the study.

Results Point of Contact

• Title: Dr.Deb Sanjay Nag
• Organization: Tata Main Hospital

debsanjay@gmail.com

+91-7763807101

Study Officials

• Ankur Dembla, DA

  Tata Main Hospital, Jamshedpur, India

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Specialist

Study Record Dates

• First Submitted: June 9, 2015
• First Posted: June 15, 2015
• Study Start: December 1, 2013
• Primary Completion: November 1, 2014
• Study Completion: December 1, 2014
• Last Updated: October 15, 2019
• Results First Posted: June 27, 2016

Record last verified: 2016-05

Data Sharing

• IPD Sharing: Will not share

Locations

IN (1)