STAND UP - Sedentary Behaviour in Older Adults: Investigating a New Therapeutic Paradigm
STAND-UP
4 other identifiers
interventional
76
1 country
2
Brief Summary
Research has shown that reducing the time spent sitting can reduce the risk of many diseases, such as diabetes and heart disease, and improve health. It is estimated that many older adults typically spend 70% of their waking day sitting, but little is known about whether reducing sitting promotes health and well-being in this age group. The aim of this research is to investigate the health effects of reducing sitting time by replacing it with short periods of standing or walking in adults over the age of 65.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Apr 2015
Typical duration for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2015
CompletedFirst Submitted
Initial submission to the registry
May 12, 2015
CompletedFirst Posted
Study publicly available on registry
May 25, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2017
CompletedJanuary 30, 2020
June 1, 2016
1.9 years
May 12, 2015
January 29, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Insulin area under the curve
Samples will be batched and analysed at the end of the study within a certified research laboratory at the Institute of Cardiovascular and Medical Sciences (ICAMS), University of Glasgow. Samples collected at the Leicester Diabetes Centre will be sent by courier in specialist containers and packed with dry ice.
3 experimental intervention study visits over an estimated period of 1 month
Secondary Outcomes (12)
Glucose area under the curve
3 experimental intervention study visits over an estimated period of 1 month
Triglyceride area under the curve
3 experimental intervention study visits over an estimated period of 1 month
1H NMR Metabolomics spectroscopy
3 experimental intervention study visits over an estimated period of 1 month
Blood pressure
3 experimental intervention study visits over an estimated period of 1 month
Felt Arousal Scale (0-5)
3 experimental intervention study visits over an estimated period of 1 month
- +7 more secondary outcomes
Study Arms (3)
Sitting
EXPERIMENTALParticipants will remain sitting throughout the test period whilst undertaking typical sedentary behaviours such as watching TV, using a computer, reading and writing. Walking and standing will be restricted.
Standing
EXPERIMENTALParticipants will be asked to break their sitting time by standing for five minutes every 30 minutes. Participants will be asked to stand in the same position with no further instructions provided. In total, individuals will accumulate 12 bouts (60 minutes) of standing throughout the test period.
Walking
EXPERIMENTALThe walking condition will be identical to standing, but the breaks in sitting time will be punctuated with five minute bouts of self-paced walking rather than standing.
Interventions
Eligibility Criteria
You may qualify if:
- Adults aged between 65 to 79 years inclusive
- Able to walk (without any assistive devices and not requiring assistance from another person)
- Ability to communicate in and understand English to participate in the informed consent process.
You may not qualify if:
- Regular purposeful exercise (≥75 minutes of self-reported vigorous exercise per week)
- Inability to stand or undertake light ambulation
- Psychological condition which limits participation in the study (e.g. dementia)
- Inability to communicate or understand English
- Steroid use
- Use of glucose lowering medication
- Inability to give informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Leicesterlead
- University of Glasgowcollaborator
- National Institute for Health Research, United Kingdomcollaborator
- National Health Service, United Kingdomcollaborator
Study Sites (2)
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Avenue
Glasgow, G12 8TA, United Kingdom
Leicester Diabetes Centre, Diabetes Research Unit, University of Leicester, Leicester General Hospital
Leicester, LE5 4PW, United Kingdom
Related Publications (1)
Yates T, Edwardson CL, Celis-Morales C, Biddle SJH, Bodicoat D, Davies MJ, Esliger D, Henson J, Kazi A, Khunti K, Sattar N, Sinclair AJ, Rowlands A, Velayudhan L, Zaccardi F, Gill JMR. Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):139-146. doi: 10.1093/gerona/gly252.
PMID: 30403772DERIVED
Related Links
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Thomas Yates
University of Leicester
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 12, 2015
First Posted
May 25, 2015
Study Start
April 1, 2015
Primary Completion
March 1, 2017
Study Completion
March 1, 2017
Last Updated
January 30, 2020
Record last verified: 2016-06