Monosodium L-glutamate (MSG) on Satiety

NCT02446106 | Completed DMC

• 1 other identifier: 12/NS/0068
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to compare energy intake following consumption 0.5% MSG versus a control with no added MSG and matched for sodium in healthy non-smoking premenopausal female adults.

Conditions

Nutrition Intervention

Keywords

Monosodium L-Glutamate (MSG); Satiety; Soups; Energy Intake; Snack Intake

Outcome Measures

Primary Outcomes (1)

• The difference in total energy intake (lunch and snack) compared with a control, as determined by food amount that subject consumed using a food scale (weigh foods before and after).

  food will be measured before and after using a food scale (weight out and in)

  8 hours 30 min Postprandial Study

Secondary Outcomes (2)

• The difference in energy intake only at lunch compared with a control, as determined by food amount that subject consumed using a food scale (weigh foods before and after).

  8 hours 30 min Postprandial Study

• The difference in energy intake of snack only compared with a control

  8 hours 30 min Postprandial Study

Other Outcomes (2)

• The difference in subjective feelings of appetite using visual analogue scales (VAS), compared with a negative control

  8 hours 30 min Postprandial Study

• Taste meal evaluation, including soup liking

  8 hours 30 min Postprandial Study

Study Arms (2)

Soup with MSG

ACTIVE COMPARATOR

0.5% MSG incorporated into a soup preload

Dietary Supplement: Soup with MSG

Control Soup

PLACEBO COMPARATOR

Negative control match for sodium (no MSG + 0.635% salt)

Dietary Supplement: Control soup no MSG

Interventions

Soup with MSG DIETARY_SUPPLEMENT

0.5% MSG + 0.48% salt

Soup with MSG

Control soup no MSG DIETARY_SUPPLEMENT

Negative control match for sodium (no MSG + 0.635% salt)

Control Soup

Eligibility Criteria

• Age: 19 Years - 60 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy Premenopausal Female, 19 to 60 yrs old
• Non-smoker
• Non-heavy Drinker
• BMI between 25 and 39.9 inclusive at the screening visit (with average BMI 30)
• no reported current or previous metabolic diseases or chronic gastrointestinal disorders
• no medically prescribed diet, no slimming diet, used to eating 3 meals a day and snacking
• No blood donation during the study
• Reported intense sporting activities ≤ 10h/w
• Reported alcohol consumption ≤14 units/w
• Informed consent signed
• Recruitment form filled out

You may not qualify if:

• Smoker
• Vegetarian
• Disliking the meals provided on the test day, have allergy or intolerance to test products or study meals
• Use of medication which interferes with study measurements (as judged by the study physician).
• Possible eating disorder (measured by SCOFF questionnaire score \>1)
• Current depression measured by BDI \<10
• Pregnant during the study period or in the six months prior to pre-study investigation
• Reported lactating 6 weeks before pre-study investigation and during the study
• Reported weight loss or gain ≥ 10 % of bodyweight during a period of six months before pre-study examination.
• Eating disorder (measured by SCOFF questionnaire, ≥2 "yes" responses)
• Reported participation in another biomedical trial 1 month before the start of the study

Sponsors & Collaborators

• Ajinomoto Co., Inc.: lead

Study Sites (1)

Leatherhead Food Research

Leatherhead, Surrey, KT22 7RY, United Kingdom

Location

MeSH Terms

Interventions

Sodium Glutamate

Intervention Hierarchy (Ancestors)

Glutamic Acid; Glutamates; Amino Acids, Acidic; Amino Acids; Amino Acids, Peptides, and Proteins; Amino Acids, Dicarboxylic

Study Officials

• Sonia Pombo, PhD

  Nutrition & Health Enquires, Leatherhead Food Research

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 8, 2015
• First Posted: May 18, 2015
• Study Start: June 1, 2012
• Primary Completion: September 1, 2012
• Study Completion: October 1, 2012
• Last Updated: May 18, 2015

Record last verified: 2015-05

Locations

GB (1)