Potential Role for Echocardiography in Adult Patients With Community-Acquired Pneumonia

NCT02441855 | Completed

• 1 other identifier: Pneumonia
• Study Type: observational
• Target: 210
• Locations: 1 country
• Sites: 1

Brief Summary

Despite the efficacy of modern treatment, community-acquired pneumonia (CAP) is the the leading cause of death. Prognostic scores have been developed to estimate the risk of adverse outcome. Several serum biomarkers have been also investigated in patients with CAP. A growing number of echocardiographic markers have been evaluated as possible predictors of prognosis in patients with pulmonary and infectious diseases such as sepsis, septic shock, human immunodeficiency virus infection, pulmonary tuberculosis, and chronic obstructive pulmonary disease. As echocardiography is a non-invasive, reliable, cost-effective, and reproducible diagnostic tool to evaluate cardiac function and structures, the investigators aimed to investigate left and right ventricular functions and aortic elastic properties in CAP patients. Furthermore, the investigators also aimed to observe relationships between echocardiographic findings and inflammatory and cardiac serum biomarkers in patients with CAP.

Conditions

Community-acquired Pneumonia

Outcome Measures

Primary Outcomes (1)

• the TAPSE value to discriminate patients with pneumonia

  the TAPSE (Tricuspid annular plane systolic excursion ) value to discriminate patients with pneumonia

  1 month

Secondary Outcomes (1)

• the BNP value to discriminate patients with pneumonia

  1 month

Study Arms (2)

pneumonia

patients with community-acquired pneumonia

Device: echocardiography

control

patients admitted to emergency department with shortness of breath

Device: echocardiography

Interventions

echocardiography DEVICE

echocardiography: Left and right ventricular functions and aortic elastic properties.

control; pneumonia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Pneumonia group is defined as patients with community acquired pneumonia diagnosis hospitalised through emergency department. The control group will be consisted of consecutive sex- and age-matched patients admitted to the emergency department.

You may qualify if:

• ≥ 18 years of age

You may not qualify if:

• Patients with active pulmonary tuberculosis
• Hospital-acquired pneumonia
• Severely immunocompromised patients
• Patients undergoing chronic dialysis
• Patients sent for ambulatory treatment

Sponsors & Collaborators

• Muğla Sıtkı Koçman University: lead

Study Sites (1)

Mugla Sitki Kocman University Education and Research Hospital

Muğla, Turkey (Türkiye)

Location

Related Publications (2)

• Biteker FS, Biteker M, Basaran O, Dogan V, Ozlek B, Yildirim B, Ozlek E, Celik O. A small pericardial effusion is a marker of complicated hospitalization in patients with community-acquired pneumonia. J Crit Care. 2018 Apr;44:294-299. doi: 10.1016/j.jcrc.2017.11.030. Epub 2017 Nov 23.

  PMID: 29247912 DERIVED

• Biteker FS, Basaran O, Dogan V, Caylak SD, Yildirim B, Sozen H. Prognostic value of transthoracic echocardiography and biomarkers of cardiac dysfunction in community-acquired pneumonia. Clin Microbiol Infect. 2016 Dec;22(12):1006.e1-1006.e6. doi: 10.1016/j.cmi.2016.08.016. Epub 2016 Sep 3.

  PMID: 27596535 DERIVED

MeSH Terms

Conditions

Community-Acquired Pneumonia

Interventions

Echocardiography

Condition Hierarchy (Ancestors)

Community-Acquired Infections; Infections; Pneumonia; Respiratory Tract Infections; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Study Officials

• Murat Biteker, Assoc. Prof.

  Muğla Sıtkı Koçman University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D

Study Record Dates

• First Submitted: May 8, 2015
• First Posted: May 12, 2015
• Study Start: March 1, 2015
• Primary Completion: May 1, 2015
• Study Completion: May 1, 2015
• Last Updated: June 4, 2015

Record last verified: 2015-06

Locations

TU (1)