The Bilateral Deficit Phenomenon, Functional and Dynamometric Assessment in Postmenopausal Women

NCT02434185 | Completed

• 1 other identifier: UCAM-BLD-1
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The bilateral deficit phenomenon (BLD) is defined as an inability of the neuromuscular system to generate maximal force when two homonymous limb operate simultaneously (bilateral contraction) with respect to the force developed when both limbs acts separately (unilateral contraction). From an applied perspective, movement patterns of bilateral homonymous limb are often developed during activities of day living, e.g. rising from a chair or opening a jar. The BLD can be considered an intrinsic property of the human neuromuscular system but could be enough important to constitute a performance-limiting factor for postmenopausal women that involves a degenerative loss of muscular strength. Therefore, a specific analysis of this phenomenon and its relation with activities of daily living, such as climbing a step and rising from a chair, is crucial for detecting variables of neuromuscular performance and develop strategies to minimize the loss of strength.

Conditions

Postmenopausal Syndrome; Muscle Weakness

Keywords

Musculoskeletal Physiological Phenomena; Postmenopause; Muscle Strength; Absorptiometry, Photon

Outcome Measures

Primary Outcomes (7)

• Assess the maximum force of lower limbs during bilateral and unilateral contraction

  Screening visit

• Assess the force-time curve during climbing a step

  Screening visit

• Assess the force-time curve during climbing rising from a chair

  Screening visit

• Assess bone mineral-free lean tissue mass by dual energy X-ray absorptiometry

  Screening visit

• Assess the fragility phenotype of the subjects

  Screening visit

• Assess the rate of force developed in time intervals (0-50, 50-100, 100-150ms) of lower limbs during bilateral and unilateral contraction

  Screening visit

• Assess fat-tissue mass and lean-tissue mass composition

  Screening visit

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Postmenopausal women not experienced in strength training or resistance, without musculoskeletal, neurological diseases, and cardiovascular limiting-factor.

You may qualify if:

• Postmenopausal women

You may not qualify if:

• Unexperienced in strength training or resistance training.
• Not musculoskeletal diseases.
• Not neurological diseases.
• Not cardiovascular limiting-diseases.
• Not fragility or pre-fragility phenotype.

Sponsors & Collaborators

• Universidad Católica San Antonio de Murcia: lead

Study Sites (1)

Catholic University of Murcia

Murcia, 30107, Spain

Location

Related Publications (1)

• Ruiz-Cardenas JD, Rodriguez-Juan JJ, Jakobi JM, Rios-Diaz J, Marin-Cascales E, Rubio-Arias JA. Bilateral deficit in explosive force related to sit-to-stand performance in older postmenopausal women. Arch Gerontol Geriatr. 2018 Jan;74:145-149. doi: 10.1016/j.archger.2017.10.023. Epub 2017 Oct 31.

  PMID: 29102831 DERIVED

MeSH Terms

Conditions

Muscle Weakness

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Juan Diego JD Ruiz-Cárdenas, BSc, MSc

  Universidad Católica San Antonio de Murcia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: BSc, MSc

Study Record Dates

• First Submitted: April 30, 2015
• First Posted: May 5, 2015
• Study Start: March 1, 2015
• Primary Completion: April 1, 2015
• Study Completion: April 1, 2015
• Last Updated: October 15, 2018

Record last verified: 2018-10

Locations

ES (1)