CHildhood ASthma and Environment Research Study - CHASER Study

NCT02433275 | Completed

• 1 other identifier: 8/2014
• Study Type: observational
• Target: 2,660
• Locations: 1 country
• Sites: 1

Brief Summary

"CHildhood ASthma and Environment Research study - CHASER study" is an observational longitudinal study in outpatient clinic of Pediatric Allergology \& Pulmonology (PAP) of Respiratory Disease Research Center (RDRC) within the Institute of Biomedicine and Molecular Immunology (IBIM) of the National Research Council (CNR) of Palermo (RDRC-IBIM CNR), Italy. The first phase - transversal study will identify determinants of pediatric asthma control The second phase - longitudinal study, in patients with persistent asthma, will be focused on:

• predictors for asthma exacerbations and loss of control
• real life adherence to asthma therapy guidelines
• phenotypic characterization through the collection of saliva samples
• assessment of alterations and inflammatory changes in the nasal mucosa through nasal brushing
• evaluation of the presence of 8-isoprostane, nicotine, cotinine and bisphenol-A through urine analysis. Chaser Project is expected to improve the knowledge of pediatric asthma in patients with different level of control, identifying predictors for asthma exacerbations and loss of control.

Conditions

Asthma

Outcome Measures

Primary Outcomes (1)

• Asthma

  5 years

Secondary Outcomes (3)

• Measures from saliva samples

  5 years

• Measures from nasal brushing

  5 years

• Measures from urine samples

  5 years

Eligibility Criteria

• Age: 5 Years - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Children

You may qualify if:

• age 5-16 years
• asthma
• not asthma

You may not qualify if:

• chest deformity
• active smoking

Sponsors & Collaborators

• Stefania La Grutta, MD: lead

Study Sites (1)

Institute of Biomedicine and Molecular Immunology, IBIM

Palermo, Palermo, 90146, Italy

Location

Related Publications (3)

• Cilluffo G, Ferrante G, Fasola S, Malizia V, Montalbano L, Ranzi A, Badaloni C, Viegi G, La Grutta S. Association between Asthma Control and Exposure to Greenness and Other Outdoor and Indoor Environmental Factors: A Longitudinal Study on a Cohort of Asthmatic Children. Int J Environ Res Public Health. 2022 Jan 4;19(1):512. doi: 10.3390/ijerph19010512.

  PMID: 35010773 DERIVED

• Erkkola RA, Virta LJ, Vahlberg T, Jartti T. Prednisolone for the first rhinovirus induced wheezing reduces use of respiratory medication. Pediatr Allergy Immunol. 2022 Jan;33(1):e13668. doi: 10.1111/pai.13668. Epub 2021 Sep 29. No abstract available.

  PMID: 34536305 DERIVED

• Cilluffo G, Han YY, Ferrante G, Dello Russo M, Lauria F, Fasola S, Montalbano L, Malizia V, Forno E, La Grutta S. The Dietary Inflammatory Index and asthma burden in children: A latent class analysis. Pediatr Allergy Immunol. 2022 Jan;33(1):e13667. doi: 10.1111/pai.13667. Epub 2021 Sep 27.

  PMID: 34528308 DERIVED

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Stefania La Grutta, MD. Senior Researcher. Coordinator of Pediatric Allergy and Asthma Research Group. Institute of Biomedicine and Molecular Immunology, IBIM, National Research Council of Palermo, Italy.

Study Record Dates

• First Submitted: April 29, 2015
• First Posted: May 4, 2015
• Study Start: September 1, 2011
• Primary Completion: February 1, 2020
• Study Completion: February 1, 2020
• Last Updated: April 13, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share

Locations

IT (1)