Explore the Association Between Neuropsychological Functions and ADHD Diagnosis and Comorbid Using Longitudinal Study in Preschool Children

NCT02433145 | Unknown DMC

• 1 other identifier: 201405086RINB
• Study Type: observational
• Target: 220
• Locations: 1 country
• Sites: 1

Brief Summary

The current study using the longitudinal study in preschool children to exam three study issues: 1) using the neuropsychological functions (ie. Behavioral inhibition, delay aversion, the variability of reaction time) among the preschool children predict the ADHD diagnosis and behavior symptoms in 1.5 years later. 2) using the behavior inhibition, delay aversion and the variability of reaction time (using the parameter among Gaussian distribution and ex-Gaussian distribution) explore the association between attention and motor inhibition problems. 3) explore the transaction effect between the neuropsychological functions and family function and parenting to predict ADHD comorbidity with oppositional defiant disorder.4) explore the association between the internalizing/ externalizing problems of ADHD and temperament. The current study has opportunity to describe and to answer the complicated problems for heterogeneous neuropsychological deficits in ADHD, and to elucidate the core issues for ADHD have comorbid with ODD. The most important contribution is to offer the empirical evidence to make a clean suggestion in ADHD diagnosis and intervention in preschool age.

Conditions

Attention Deficit/Hyperactivity Disorder

Keywords

ADHD in preschoolers; neuropsychological functions; behavior inhibition; family function and parenting

Outcome Measures

Primary Outcomes (1)

• The error rate and hit reaction time in the judgements on color flanker response inhibition test which measured by the e-prime program on the laptop

  up to 3 years

Secondary Outcomes (1)

• The error rate and hit reaction time in the day-night stroop test which measured by the e-prime program on the laptop

  up to 3 years

Other Outcomes (1)

• The final balloon numbers and eaction time in delay aversion test which measured by the e-prime program on the laptop

  up to 3 years

Eligibility Criteria

• Age: 4 Years - 5 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

We will recruit 100 typical developmental control and 120 ADHD high risk preschool children at time 1, and we using the diagnosis at time 2 to have three groups in this study (ADHD persistent, ADHD remission and typical developmental control).

You may qualify if:

• Control group
• The subjects without ADHD.
• Ages range from 4 to 5
• Full scale IQ ≥ 80
• The subjects who and whose parents consent to this study.
• ADHD high risk group
• Patients who have clinically diagnosis of DSM-IV ADHD confirmed by the Psychiatrists or have the risk of becoming ADHD confirmed by the ADHD behavioral rating scales.
• Ages range from 4 to 5
• Full scale IQ ≥ 80
• Patients who and whose parents consent to this study.

You may not qualify if:

• Mental Retardation
• Schizophrenia, Schizoaffective Disorder
• Mood Disorders
• Organic Psychosis
• Learning Disorder
• Pervasive Developmental Disorder

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

RECRUITING

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Susan Shur-Fen Gau, MD, PhD

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Susan Shur-Fen Gau, MD, PhD

CONTACT

02-23123456; gaushufe@ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 29, 2015
• First Posted: May 4, 2015
• Study Start: October 1, 2014
• Primary Completion: August 1, 2017
• Study Completion: August 1, 2017
• Last Updated: May 4, 2015

Record last verified: 2015-04

Locations

TW (1)