NCT02426138

Brief Summary

Food insecurity, defined as difficulty accessing food owing to cost, affects 1 in 5 diabetes patients. To address this, the investigators are conducting a pilot randomized controlled trial of medically tailored meal delivery (MTM). The pilot study has two specific aims: Aim 1: To determine the effect of receiving MTM on dietary quality for food insecure diabetes patients with hyperglycemia Aim 2: To determine the feasibility and acceptability of the program as a medical intervention and refine the program as needed for testing in larger studies. This study is a crossover randomized controlled pilot trial, where approximately 50 participants, 25 in each arm, will be randomized to receipt of 12 weeks of MTM, to begin immediately, or waitlist control. After 12 weeks, the groups will crossover, with the waitlist control group now receiving 12 weeks of MTM. At baseline, 12 weeks, and 24 weeks, the participants will complete assessments of their dietary quality (HEI score), psychosocial measures such as diabetes distress and food insecurity, along with measures of body mass index, blood pressure, hemoglobin A1c, and lipids.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
44

participants targeted

Target at P25-P50 for not_applicable diabetes

Timeline
Completed

Started Apr 2015

Typical duration for not_applicable diabetes

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 7, 2015

Completed
25 days until next milestone

Study Start

First participant enrolled

April 1, 2015

Completed
23 days until next milestone

First Posted

Study publicly available on registry

April 24, 2015

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 31, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2017

Completed
2.2 years until next milestone

Results Posted

Study results publicly available

October 30, 2019

Completed
Last Updated

October 30, 2019

Status Verified

October 1, 2019

Enrollment Period

2.3 years

First QC Date

March 7, 2015

Results QC Date

April 15, 2019

Last Update Submit

October 7, 2019

Conditions

Outcome Measures

Primary Outcomes (1)

  • Healthy Eating Index 2010 Score

    Calculated using data from ASA24 24-hour dietary recall tool Healthy Eating Index 2010 Score Minimum and Maximum range = 0 to 100 Higher scores indicate better diet quality The score is an average of the three-time periods that data was collected

    Average of 3 24-hour food recalls per study period (on and off meals; one in-person visit and 2 over the phone at 4 and 8 weeks into the study)

Secondary Outcomes (2)

  • Number of Participants With Food Insecurity

    Measured at end of On-Meals Period and end of Off-Meals Period for each participant

  • Diabetes Distress Scale

    Measured at end of On-Meals Period and end of Off-Meals Period for each participant

Other Outcomes (14)

  • Hemoglobin A1c

    Measured at end of On-Meals Period and end of Off-Meals Period for each participant

  • LDL Cholesterol

    Measured at end of On-Meals Period and end of Off-Meals Period for each participant

  • Body Mass Index

    Measured at end of On-Meals Period and end of Off-Meals Period for each participant

  • +11 more other outcomes

Study Arms (2)

Med. Tailored Meal Delivery, Usual Care + Choose Myplate

EXPERIMENTAL

Participants will receive 12 weeks of medically tailored meal delivery, comprising approximately half of their weekly caloric intake and consisting of foods prepared under the supervision of a registered dietitian to be compatible with a diabetes diet. They will also receive usual diabetes care and a Choose MyPlate healthy eating brochure for 12 weeks.

Other: Medically Tailored Meal Delivery (MTM)Other: Usual Care + Choose MyPlate

Usual Care + Choose Myplate, Med. Tailored Meal Delivery

ACTIVE COMPARATOR

Participants will receive usual diabetes care and a Choose MyPlate healthy eating brochure for 12 weeks.

Other: Usual Care + Choose MyPlate

Interventions

Patients will receive delivery of medically tailored meals for 12 weeks

Med. Tailored Meal Delivery, Usual Care + Choose Myplate

Patients will receive usual diabetes care + a Choose MyPlate healthy eating brochure for 12 weeks

Med. Tailored Meal Delivery, Usual Care + Choose MyplateUsual Care + Choose Myplate, Med. Tailored Meal Delivery

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Diagnosis of type 2 diabetes
  • Age 18 years or older
  • HbA1c level \>8.0%
  • Report food insecurity as indicated by the 2-item USDA Food Security Survey Module13
  • Willing to commit to random assignment to either receive CS meals immediately or as a waitlist control
  • Stable health, with no severe medical comorbidities that might interfere with their ability to participate in the intervention, such as severe psychiatric illness or imminent hospitalization
  • Be willing to keep a food diary
  • Be willing to attend and complete a baseline, 12 week, and 24 week assessment at MGH
  • Be able to understand and communicate effectively in English
  • Have a primary care physician within the MGH practice based research network
  • Live in an area where Community Servings can deliver meals
  • Ability to store and prepare Community Servings meals

You may not qualify if:

  • Must not be pregnant or planning pregnancy in the next year
  • Currently enrolled in another diabetes study Food allergy that would prohibit consumption of meals
  • Receiving episodic treatments that may increase blood glucose levels (e.g. prednisone)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Location

Related Publications (2)

  • Berkowitz SA, Delahanty LM, Terranova J, Steiner B, Ruazol MP, Singh R, Shahid NN, Wexler DJ. Medically Tailored Meal Delivery for Diabetes Patients with Food Insecurity: a Randomized Cross-over Trial. J Gen Intern Med. 2019 Mar;34(3):396-404. doi: 10.1007/s11606-018-4716-z. Epub 2018 Nov 12.

  • Berkowitz SA, Shahid NN, Terranova J, Steiner B, Ruazol MP, Singh R, Delahanty LM, Wexler DJ. "I was able to eat what I am supposed to eat"-- patient reflections on a medically-tailored meal intervention: a qualitative analysis. BMC Endocr Disord. 2020 Jan 20;20(1):10. doi: 10.1186/s12902-020-0491-z.

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Limitations and Caveats

Short-term study designed to test change in diet quality only. Not designed for clinical endpoints Single center study in one region of US

Results Point of Contact

Title
Dr. Seth A. Berkowitz
Organization
University of North Carolina at Chapel Hill

Study Officials

  • Seth A Berkowitz, MD MPH

    Massachusetts General Hospital

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Instructor in Medicine

Study Record Dates

First Submitted

March 7, 2015

First Posted

April 24, 2015

Study Start

April 1, 2015

Primary Completion

July 31, 2017

Study Completion

July 31, 2017

Last Updated

October 30, 2019

Results First Posted

October 30, 2019

Record last verified: 2019-10

Data Sharing

IPD Sharing
Will not share

Locations