Effect of Pursed Lips Breathing on Chest Wall, Mobility Diaphragmatic and Exercise Tolerance in Patients With Chronic Obstructive Pulmonary Disease

NCT02424331 | Completed DMC

• 1 other identifier: 19309213.3.0000.5208
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to evaluate the acute effect of PLB technique on diaphragmatic mobility, the kinematics of the thoracoabdominal complex analysis of lung volumes and exercise tolerance in patients with Chronic Obstructive Pulmonary Disease (COPD). This is a study randomized cross-over clinical trial and blind, in subjects with Chronic Obstructive Pulmonary Disease (COPD) according to criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) (FEV1 / FVC \<0.7 and FEV1 \<80% predicted) selected at the Clinical Hospital of the Federal University of Pernambuco (UFPE) and Otavio de Freitas General Hospital (HGOF). The investigators recruited 13 patients COPD (according to previous sample calculation) aged between 40 and 80 years, of both sexes. The first day was held evaluation of lung function, respiratory muscle strength, body composition, dyspnea index and functional capacity. On the second day was held evaluation of thoracoabdominal complex kinematics by plethysmography Optoelectronics (OEP) with Quiet Breathing (QB) or pursed-lips breathing (PLB). Lung volumes with 2 minutes with QB and 6 minutes PLB or only 6 minutes by QB as randomization were observed. Before and after performing the requested breathing pattern diaphragmatic mobility was observed by Ultrasonography (US) and requested the patient an Inspiratory Capacity maneuver (IC). The evaluator who performed the ultrasound was blinded as to the beginning of the breathing pattern of order performed by the patient.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

Chronic Obstructive Pulmonary Disease; Respiratory mechanics; Plethysmography; Diaphragm; Respiratory muscles; Breathing exercises

Outcome Measures

Primary Outcomes (3)

• Chest wall (Analysis of lung volumes)

  (L) by plethysmography optoelectronics.

  One day during eight minutes

• Mobility diaphragmatic (mobility diaphragmatic (mm) by Ultrassonography)

  Analysis of mobility diaphragmatic (mm) by Ultrassonography.

  One day, before and after eight minutes of pursed lips breathing

• Exercise tolerance (Glittre AVD-Test)

  Analysis by Glittre AVD-Test (capacity functional test) observing the test execution time (s).

  One day, for six minutes approximately. The test will be repeated after 20 minutes of rest.

Secondary Outcomes (1)

• Dyspnea (Borg and MRC Scale)

  One day, before and after implementation of Glittre-ADL Test

Study Arms (1)

Quiet Breathing or Pursed Lips Breathing

EXPERIMENTAL

Free or natural breathing for six minutes.

Other: Pursed Lips Breathing; Other: Quiet Breathing

Interventions

Pursed Lips Breathing OTHER

Pursed Lips Breathing for six minutes.

Quiet Breathing or Pursed Lips Breathing

Quiet Breathing OTHER

Quiet Breathing or Pursed Lips Breathing

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• COPD diagnosis with stage II-IV (GOLD),
• Stable clinical condition (no exacerbation or hospital admission in the last four weeks preceding the study)
• Absence of other disease that may potentially contribute to dyspnea (heart disease, congestive heart failure, neuromuscular diseases, severe postural changes)

You may not qualify if:

• BMI\> 30 kg / m2
• Musculoskeletal limitations
• Use of oxygen therapy
• Extreme discomfort during the procedure application

Sponsors & Collaborators

• Universidade Federal de Pernambuco: lead

Study Sites (1)

Clinical Hospital

Recife, Pernambuco, Brazil

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Armele D Andrade, Dra

  Universidade Federal de Pernambuco

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master

Study Record Dates

• First Submitted: March 5, 2015
• First Posted: April 23, 2015
• Study Start: March 1, 2014
• Primary Completion: January 1, 2015
• Study Completion: March 1, 2015
• Last Updated: April 23, 2015

Record last verified: 2015-04

Locations

BR (1)