Features Emotional Responses in Adults With Autism: Comparison With Bipolar Disorder (REMBAU)

NCT02423499 | Completed DMC

• 2 other identifiers: PHAO13-ML/REMBAU2014-A00431-46
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to identify the specific characteristics of Autism Spectrum Disorder (ASD) in emotional response profiles and shared with Bipolar Disorder (BD) characteristics.

Conditions

Autism Spectrum Disorder; Bipolar Disorder

Keywords

Autism Spectrum Disorder; Bipolar Disorder; Emotions

Outcome Measures

Primary Outcomes (1)

• Physiological emotional response during emotion elicitation in a laboratory session (Pupil size measured by eye tracking, heart rate, electrodermal response, breath rate) during emotion elicitation in a laboratory session

  average 1 hour

Secondary Outcomes (4)

• Subjective emotional response during emotion elicitation in a laboratory session

  average 1 hour

• Facial emotional response during emotion elicitation in a laboratory session

  average 1 hour

• Experience sampling method in real life during a week (emotions, activities, social context, burden)

  within the first 7 days after inclusion

• Physiological emotional response in real life (heart rate, electrodermal response, breath rate, actimetry)

  within the first 24h approx. after inclusion

Study Arms (3)

Autism Spectrum Disorder

Autism Spectrum Disorder adults without intellectual disability

Bipolar Disorder

Bipolar Disorder adults during normothymic phase of illness

Healthy Volonteers

Healthy adults

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

ASD subjects will be recruited at Centre Universitaire de Pédopsychiatrie, CHRU de Tours, FRANCE. BD subjects will be recruited at Clinique Psychiatrique Universitaire, CHRU de Tours, FRANCE. Healthy volunteers will be recruited at Centre d'Inverstigation Clinique, CHRU de Tours, FRANCE.

You may qualify if:

• For all participants:
• Age between 18 and 50 years
• Normal vision (or corrected)
• Absence of neurological disorder (epilepsy , head trauma, ... )
• Ability to understand information about the protocol
• Informed and signed consent
• normal mood (euthymia)
• normal or high intelligence
• Subjects with ASD:
• Subjects with an autism spectrum disorder according to the DSM-5
• The diagnosis is confirmed by diagnostic interviews: ADI- R (Autism Diagnostic Interview-Revised) and / or ADOS (Autism Diagnostic Observation Schedule ) .
• Subjects with bipolar disorder:
• Diagnosis of bipolar disorder according to DSM-IV-TR or DSM -5
• The diagnosis is confirmed by the MINI 6.0 (The Mini-International Neuropsychiatric Interview) .
• Healthy volunteers:

Sponsors & Collaborators

• University Hospital, Tours: lead

Study Sites (1)

LEMAIRE

Tours, 37044, France

Location

MeSH Terms

Conditions

Autism Spectrum Disorder; Bipolar Disorder

Condition Hierarchy (Ancestors)

Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders; Bipolar and Related Disorders; Mood Disorders

Study Officials

• Frédérique BONNET- BRILHAULT, Pr

  University Center of Child and Adolescent Psychiatry, University Hospital of Tours

  PRINCIPAL INVESTIGATOR

• Wissam EL-HAGE, Pr

  University Psychiatric Clinic, University Hospital of Tours

  PRINCIPAL INVESTIGATOR

• Valérie GISSOT, MD-PHD

  Clinical Investigation Center, INSERM 14 15, University Hospital of Tours

  PRINCIPAL INVESTIGATOR

• Mathieu LEMAIRE, MD-PHD

  University Center of Child and Adolescent Psychiatry, University Hospital of Tours

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 3, 2015
• First Posted: April 22, 2015
• Study Start: May 19, 2015
• Primary Completion: May 19, 2021
• Study Completion: May 26, 2021
• Last Updated: June 15, 2026

Record last verified: 2026-06

Locations

FR (1)