Exercise Genes: Genomic Association With Exercise Reinforcement

NCT02416882 | Completed

• 1 other identifier: GFHNRC405
• Study Type: interventional
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

This study tests whether different physical activity patterns are linked an individual's genes.

Conditions

Overweight; Obesity; Physical Activity

Keywords

active; not active; normal body weight

Outcome Measures

Primary Outcomes (3)

• Relative reinforcing value (RRV) of physical activity

  RRV of physical activity will be assessed by evaluating the number of responses (mouse button presses) a subject is willing to complete to gain access to physical activity or a sedentary alternative.

  Week 0 (Cross-sectional)

• Preference for intense physical activity and tolerance for exercise discomfort

  Preference for intense physical activity and tolerance for exercise discomfort will be assessed by self-report questionnaire responses.

  Week 0 (Cross-sectional)

• Genotypes of 23 small nucleotide polymorphisms (SNPs) previously identified to influence central dopamine release or uptake, reward, or physical activity

  SNP genotyping will be performed on 3-5 ml samples of whole blood collected in ethylenediaminetetraacetic acid (EDTA)-containing tubes followed by allelic-discrimination analysis for the amplification and identification of each SNP.

  Week 0 (Cross-sectional)

Study Arms (2)

Aerobic Exercise vs Sedentary Option

OTHER

Relative Reinforcing Value of aerobic exercise versus sedentary activity will be determined.

Other: Aerobic Exercise; Other: Sedentary Option

Resistance Exercise vs Sedentary Option

OTHER

Relative Reinforcing Value of resistance exercise versus sedentary activity will be determined.

Other: Resistance Exercise; Other: Sedentary Option

Interventions

Aerobic Exercise OTHER

Subjects will sample and rate their liking of three cardiovascular machines (treadmill, cycle ergometer, elliptical step ergometer) to determine which one will be used during the test.

Aerobic Exercise vs Sedentary Option

Resistance Exercise OTHER

Subjects will sample and rate their liking of three different resistance training circuits (upper body, lower body, core) to determine which one will be used during the test.

Resistance Exercise vs Sedentary Option

Sedentary Option OTHER

Subjects will rate their liking of three sedentary activities (reading magazines, playing puzzles, completing word games) as an alternative to exercise.

Aerobic Exercise vs Sedentary Option; Resistance Exercise vs Sedentary Option

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI within 18.5-35.0 kg/m2
• Healthy enough to exercise
• Active or inactive (not exercising at this time)

You may not qualify if:

• Taking any drugs that affect energy expenditure (e.g., thyroid, glucose-lowering drugs)
• Have gained or lost more than 5% of body weight over the past 6 months
• Use tobacco
• Pregnant or lactating or plan to become pregnant in the next 6 months
• Have any health conditions that prevent the individual from safely exercising (e.g., cardiovascular, liver, endocrine, or pulmonary diseases)

Sponsors & Collaborators

• USDA Grand Forks Human Nutrition Research Center: lead

Study Sites (1)

USDA Grand Forks Human Nutrition Research Center

Grand Forks, North Dakota, 58203, United States

Location

MeSH Terms

Conditions

Overweight; Obesity; Motor Activity

Interventions

Exercise; Resistance Training

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human

Study Officials

• James N Roemmich, PhD

  USDA Grand Forks Human Nutrition Research Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: FED
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 2, 2015
• First Posted: April 15, 2015
• Study Start: April 1, 2015
• Primary Completion: November 1, 2015
• Study Completion: December 1, 2015
• Last Updated: April 11, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)