Oxidative Damage and Antioxidant Mechanisms in COPD

NCT02406053 | Completed DMC

• 2 other identifiers: YYU-016YYU-2015-66
• Study Type: observational
• Target: 111
• Locations: 0 countries
• Sites: N/A

Brief Summary

The environmental pollutants and endogenous reactive oxygen metabolites from inflammatory cells exert substantial pathological effects on the lung cells \[1\]. Oxidative stress (OS) is a major factor that plays a significant role in lung cancer (LC) \[2\], chronic obstructive pulmonary disease (COPD) \[3\] and obstructive sleep apnea syndrome (OSAS) \[4, 5\]. The current evidence suggests that OS takes part in the mechanisms involved in initiation, promotion and progression of respiratory diseases. The major exposures that cause OS can be summarized as smoking, and ambient air pollution that contains particulate matter smaller than aerodynamic diameter of 2.5 µm \[6-8\]. Epidemiological and clinical studies showed that the overall outcome of pulmonary OS is increased mortality due to increased incidence of respiratory diseases \[9\].

Conditions

Respiratory Diseases

Keywords

lung cancer; antioxidants; oxidative damage

Outcome Measures

Primary Outcomes (1)

• Oxidative damage by evaluating the oxidative and antioxidant biomarkers

  This study aimed to evaluate the oxidative damage in these diseases by evaluating the oxidative and antioxidant biomarkers

  4 months

Study Arms (4)

OSAS

Obstructive sleep apnea syndrome

Genetic: oxidative and antioxidant biomarkers

COPD

Chronic obstructive pulmonary disease

Genetic: oxidative and antioxidant biomarkers

LC

Lung cancer

Genetic: oxidative and antioxidant biomarkers

HC

Healthy controls

Genetic: oxidative and antioxidant biomarkers

Interventions

oxidative and antioxidant biomarkers GENETIC

the oxidative damage in these diseases by evaluating the oxidative and antioxidant biomarkers.

COPD; HC; LC; OSAS

Eligibility Criteria

• Age: 38 Years - 79 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A total of 111 participants (35 females, 76 males) with OSAS (n=29), COPD (n=26) and LC (n=28), and healthy controls (n=28) were included in the study.

You may qualify if:

• Malondialdehyde (MDA), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG), and coenzyme Q10 (CoQ10) levels were evaluated in the blood samples of patients with COPD, LC, and OSAS by high-pressure liquid chromatography method.

You may not qualify if:

• The diagnosis of lung cancer was based on the analysis of biopsy or cytologic specimens obtained by bronchoscopic examination, transthoracic biopsy or surgery. The patients Who hadn't have chemo or/and radiotherapy were included to the study.

Sponsors & Collaborators

• Yuzuncu Yil University: lead

Related Publications (1)

• Sunnetcioglu A, Alp HH, Sertogullarindan B, Balaharoglu R, Gunbatar H. Evaluation of Oxidative Damage and Antioxidant Mechanisms in COPD, Lung Cancer, and Obstructive Sleep Apnea Syndrome. Respir Care. 2016 Feb;61(2):205-11. doi: 10.4187/respcare.04209. Epub 2015 Nov 24.

  PMID: 26604330 DERIVED

MeSH Terms

Conditions

Respiratory Tract Diseases; Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases

Study Officials

• AYSEL SUNNETCIOGLU, Phd

  Yuzuncu Yil University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department of Pulmory Diseas Aysel Sünnetçioğlu

Study Record Dates

• First Submitted: March 16, 2015
• First Posted: April 2, 2015
• Study Start: April 1, 2014
• Primary Completion: July 1, 2014
• Study Completion: July 1, 2014
• Last Updated: April 2, 2015

Record last verified: 2015-03