Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)
ECCSTUD
1 other identifier
observational
28
1 country
1
Brief Summary
Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). This study aims to investigate the effects of CPB on renal perfusion, filtration and oxygenation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Oct 2011
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2011
CompletedFirst Submitted
Initial submission to the registry
March 27, 2015
CompletedFirst Posted
Study publicly available on registry
April 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2016
CompletedResults Posted
Study results publicly available
May 7, 2019
CompletedMay 7, 2019
February 1, 2019
4.2 years
March 27, 2015
April 27, 2018
February 4, 2019
Conditions
Outcome Measures
Primary Outcomes (3)
Renal Blood Flow (RBF)
Renal blood flow measured with PAH clearance
6 hours
Glomerular Filtration Rate (GFR)
GFR measured by renal extraction of 51Cr-EDTA
6 hours
Renal Oxygenation
Renal oxygen extraction, defined as renal oxygen consumption divided by renal oxygen delivery
6 hours
Secondary Outcomes (2)
Excretion of NAG
24 hours
Development of Acute Kidney Injury (AKI)
72 hours
Interventions
During cardiac surgery, the subjects are routinely undergoing cardiopulmonary bypass
Eligibility Criteria
Elective complex cardiac surgery
You may qualify if:
- Preserved left ventricular function (LVEF \> 50%)
- Normal preoperative S-creatinine
You may not qualify if:
- Contraindications to radiocontrast
- Cardiac transplantation och dissection
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of thoracic anesthesia, Sahlgrenska University Hospital
Gothenburg, 41345, Sweden
Related Publications (1)
Lannemyr L, Bragadottir G, Redfors B, Ricksten SE. Effects of milrinone on renal perfusion, filtration and oxygenation in patients with acute heart failure and low cardiac output early after cardiac surgery. J Crit Care. 2020 Jun;57:225-230. doi: 10.1016/j.jcrc.2019.12.022. Epub 2020 Jan 6.
PMID: 31919012DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Lukas Lannemyr
- Organization
- Västra Götalandsregionen
Study Officials
- PRINCIPAL INVESTIGATOR
Sven-Erik Ricksten, Professor
Sahlgrenska Academy, dept of clinical science
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
March 27, 2015
First Posted
April 1, 2015
Study Start
October 1, 2011
Primary Completion
December 1, 2015
Study Completion
January 1, 2016
Last Updated
May 7, 2019
Results First Posted
May 7, 2019
Record last verified: 2019-02