Computer-based Attention Training in Patients With Acquired Brain Injury

NCT02399293 | Completed

• 1 other identifier: hnrc_nback
• Study Type: interventional
• Target: 78
• Locations: 0 countries
• Sites: N/A

Brief Summary

Investigates computer based cognitive rehabilitation and training using the N-back task with a Visual Search task as an active control. The overall purpose is to provide (further) evidence about the efficacy (or lack of efficacy) of the N-back task and to find points of convergence and divergence between patients with acquired brain injury and non-impaired subjects.

Conditions

Brain Injuries

Keywords

Cognitive training; Cognitive rehabilitation; Acquired brain injury; N-back; Visual Search; Cognitive transfer

Outcome Measures

Primary Outcomes (1)

• Change from baseline Raven's advanced progressive matrices at the end of training

  within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.

Secondary Outcomes (5)

• Change from baseline WAIS-III Working Memory Index at the end of training

  within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.

• Change from baseline WAIS-III Processing Speed Index at the end of training

  within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.

• Change from baseline Operation Span at the end of training

  within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.

• Change from baseline Stroop color-text interference at the end of training

  within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.

• Change from baseline AMPS at the end of training

  within five days after 20 full training days has been completed. Expected 3-6 weeks after baseline.

Study Arms (4)

Patient N-back

EXPERIMENTAL

Patients training the N-back task

Behavioral: N-back

Patient Visual Search

ACTIVE COMPARATOR

Patients training the Visual-Search task

Behavioral: Visual Search

Non-impaired N-back

EXPERIMENTAL

Non-impaired training the N-back task

Behavioral: N-back

Non-impaired Visual Search

ACTIVE COMPARATOR

Non-impaired training the Visual-Search task

Behavioral: Visual Search

Interventions

N-back BEHAVIORAL

The N-back task required patients to monitor a continuous sequence of stimuli (in this experiment audio and visual stimuli). Press a button if the current stimulus is the same as that shown N back in the sequence. N increases if performance is good and decreases if performance is poor. Subjects train for 20 days, 12 blocks a day, 20+N trials per block. That is 240 blocks in total. A minimum of 10 blocks per day counts as a successfully trained day.

Non-impaired N-back; Patient N-back

Visual Search BEHAVIORAL

The Visual Search task consists of a NxN array of shapes. Press the button if a certain target stimulus is present in this array. N increases if performance is good and decreases if performance is poor. Subjects train for 20 days, 12 blocks a day, 20+N trials per block. That is 240 blocks in total. A minimum of 10 blocks per day counts as a successfully trained day.

Non-impaired Visual Search; Patient Visual Search

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• subjects should be able to do both task at level at the time of recruitment
• Informed consent
• (for brain injured patients) training must not interfere with treatment as usual.
• (for brain injured patients) no symptoms which hinder testing and training. I.e. aphasia, deafness, tetraplegia etc.

Sponsors & Collaborators

• University of Aarhus: lead
• Regionshospitalet Hammel Neurocenter: collaborator

MeSH Terms

Conditions

Brain Injuries

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Officials

• Jonas Lindeløv, M.Sc.

  Hammel Neurocenter

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.sc.

Study Record Dates

• First Submitted: March 11, 2015
• First Posted: March 26, 2015
• Study Start: April 1, 2013
• Primary Completion: February 1, 2014
• Study Completion: September 1, 2014
• Last Updated: March 26, 2015

Record last verified: 2015-03