Trials Sponsors Conditions Drugs Pricing

Conditions

Pediatric Obesity

Keywords

ObesityPediatric

Outcome Measures

Primary Outcomes (1)

Fat Biopsies
1\) To test whether the reduced transcription of key lipogenic/adipogenic genes in abd SAT in obese adolescents with a High VAT/SAT ratio translates functionally into a reduced in vivo TG synthesis and adipocyte proliferation, which in turn will contribute to ectopic fat accumulation and IR.
Baseline

Secondary Outcomes (1)

MRI
Baseline

Study Arms (4)

High VAT/SAT high Palmitate Diet

Subjects with a high ratio of visceral to subcutaneous fat consuming high Palmatite oil diet for 12 weeks

Other: Palmitate Diet

Low VAT/SAT

Subjects with a low ratio of visceral to subcutaneous fat

Other: Palmitate Diet

Lean Controls

Lean control

High VAT/SAT- low Palmitate Diet

Subjects with a high ratio of visceral to subcutaneous fat consuming low Palmatite oil diet for 12 weeks

Interventions

Palmitate DietOther

Subject with high VAT/SAT ratio will be randomized to a high or low palmitate oil diet.

High VAT/SAT high Palmitate DietLow VAT/SAT

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age12 Years - 18 Years

Sexall

Healthy VolunteersYes

Age GroupsChild (0-17), Adult (18-64)

Sampling MethodNon-Probability Sample

Study Population

Obese adolescents

You may qualify if:

Overweight (85-95th% age and gender specific) or Obese (\>95th% age and gender specific)

Sponsors & Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIHcollaborator
Yale University
Otherlead

Study Sites (1)

Yale

New Haven, Connecticut, 06511, United States

Biospecimen

Retention: SAMPLES WITHOUT DNA

Basal plasma samples for measurements of glucose and glycerol enrichment, and glucose, insulin FFAs, leptin, C-peptide, glucagon, adiponectin, cortisol, growth hormone, catecholamines and amino acids, will be collected.

MeSH Terms

Conditions

Pediatric ObesityObesity

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

Sonia Caprio, MD
Yale University
PRINCIPAL INVESTIGATOR

Enrollment

26 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: CROSS SECTIONAL
Target Duration: 12 Weeks
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

March 16, 2015

First Posted

March 20, 2015

Study Start

April 2016

Date type not reported

This date has not been verified as actual or estimated.

Study to Investigate Adipocyte Cell and Lipid Turnover in Obese Adolescents

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (4)

High VAT/SAT high Palmitate Diet

Low VAT/SAT

Lean Controls

High VAT/SAT- low Palmitate Diet

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (4)

High VAT/SAT high Palmitate Diet

Low VAT/SAT

Lean Controls

High VAT/SAT- low Palmitate Diet

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations