High-intensity Interval Versus Combined Exercise Training in CHF

NCT02387411 | Unknown

• 1 other identifier: not applied
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic heart failure (CHF) is a clinical syndrome presented with central, cardiac deterioration as well as peripheral vascular and muscular abnormalities, resulting finally to reduced exercise tolerance, quality of life and mortality rates. Exercise training is a major component of rehabilitation / secondary prevention interventions, inducing significant beneficial changes in mechanisms of pathophysiology, exercise tolerance, functional capacity and quality of life, while a positive impact on hospitalization and mortality reduction should not be also excluded. There has been growing interest in the characteristics and modalities of exercise training able to induce optimal benefits. High intensity and interval mode have been shown to induce greater benefits than moderate intensity and continuous mode regimes. Additionally, there has been sound rationale for the inclusion of strength training, which has been also shown able to yield benefits in terms of exercise capacity and quality of life. However, there haven't been much data on the so called combined regimes, which include both aerobic exercise and strength training. This study aims at investigating the effects of combined high-intensity interval and strength training compared to high-intensity interval exercise alone in CHF.

Conditions

Heart Failure

Keywords

heart failure; aerobic exercise; strength training; cardiopulmonary rehabilitation; high-intensity exercise training

Outcome Measures

Primary Outcomes (1)

• aerobic exercise capacity (assessed by cardiopulmonary exercise testing)

  3 months

Secondary Outcomes (4)

• strength exercise capacity (assessed by 1-repetition maximum test)

  3 months

• quality of life (assessed by MLWHF questionnaire)

  3 months

• quadriceps local adaptations (assessed by muscle biopsies)

  3 months

• quadriceps cross sectional area (assessed by CT)

  3 months

Study Arms (2)

Interval group

ACTIVE COMPARATOR

high-intensity interval exercise training

Other: High-intensity interval exercise training

Combined group

ACTIVE COMPARATOR

combined exercise training

Other: Combined exercise training

Interventions

High-intensity interval exercise training OTHER

High-intensity interval exercise training \[4 reps \* (4 min at 80% VO2peak + 3 min at 50% VO2peak)\]

Interval group

Combined exercise training OTHER

High intensity \[2 reps \* (4 min at 80% VO2peak + 3 min at 50% VO2peak)\] and strength exercise training (2-4 sets, 10-12 reps, 60-65% 1RM, for quadriceps and hamstrings, 14 min in total)

Combined group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• stable heart failure
• ejection fraction \<=45%
• optimal medical treatment
• NYHA class \<=III

You may not qualify if:

• contraindications for maximal cardiopulmonary exercise testing (CPET)
• moderate to severe COPD
• inability to follow exercise programs due to orthopaedic problems

Sponsors & Collaborators

• University of Athens: lead

Study Sites (1)

Cardiopulmonary Exercise Testing & Rehabilitation Laboratory, 1st Critical Care Dpt, School of Medicine, University of Athens

Athens, 10675, Greece

Location

Related Publications (3)

• Tryfonos A, Tzanis G, Karatzanos Epsilon, Koutsilieris M, Nanas S, Philippou A. Inflammation- and Tissue Remodeling-Related Gene Responses in Skeletal Muscle of Heart Failure Patients Following High-Intensity Interval Training. Rev Cardiovasc Med. 2023 Feb 6;24(2):46. doi: 10.31083/j.rcm2402046. eCollection 2023 Feb.

  PMID: 39077398 DERIVED

• Alshamari M, Kourek C, Sanoudou D, Delis D, Dimopoulos S, Rovina N, Nanas S, Karatzanos E, Philippou A. Does the Addition of Strength Training to a High-Intensity Interval Training Program Benefit More the Patients with Chronic Heart Failure. Rev Cardiovasc Med. 2023 Jan 16;24(1):29. doi: 10.31083/j.rcm2401029. eCollection 2023 Jan.

  PMID: 39076879 DERIVED

• Tryfonos A, Tzanis G, Pitsolis T, Karatzanos E, Koutsilieris M, Nanas S, Philippou A. Exercise Training Enhances Angiogenesis-Related Gene Responses in Skeletal Muscle of Patients with Chronic Heart Failure. Cells. 2021 Jul 28;10(8):1915. doi: 10.3390/cells10081915.

  PMID: 34440684 DERIVED

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Serafim Nanas, MD, Prof.

  Cardiopulmonary Exercise Testing & Rehabilitation Laboratory, 1st Critical Care Dpt, School of Medicine, University of Athens, Greece

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof Critical Care Medicine

Study Record Dates

• First Submitted: February 19, 2015
• First Posted: March 13, 2015
• Study Start: May 1, 2010
• Primary Completion: June 1, 2015
• Study Completion: June 1, 2015
• Last Updated: March 13, 2015

Record last verified: 2015-03

Locations

GR (1)