Identification of Genomic Changes in Families Having Multiple Members With Tumors

NCT02386241 | Terminated DMC

• 1 other identifier: 14BN108
• Study Type: observational
• Target: 4
• Locations: 1 country
• Sites: 1

Brief Summary

This study will compare genomic alterations between the parents and the patients with high-grade glioma.

Conditions

Glioma

Keywords

brain tumor

Outcome Measures

Primary Outcomes (1)

• Total genomic sequencing

  Researchers will perform total genomic sequencing using next generation sequencing technology to identify common variants associated with familial brain tumors. Upon sequencing of the genomic material, the data analysis will be done using standard statistical methods. We will use bioinformatics tools (high throughput sequencing of genome) to identify genomic changes between parents and patients.

  within 30 days of blood or saliva collection

Interventions

saliva or blood sample collection OTHER

Single saliva or blood sample measuring 10mL for genomic analysis.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Families having multiple members (1st degree) with tumors.

You may qualify if:

• years or older.
• Family history of brain tumor in first degree relative

You may not qualify if:

• less than 18 years

Sponsors & Collaborators

• St. Joseph's Hospital and Medical Center, Phoenix: lead
• Translational Genomics Research Institute: collaborator

Study Sites (1)

Barrow Neurological Institute at St. Joseph's Hospital Medical Center

Phoenix, Arizona, 85013, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

A single saliva or blood sample measuring 10mL for genomic analysis.

MeSH Terms

Conditions

Glioma; Brain Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Peter Nakaji, MD

  Saint Joseph's Hospital and Medical Center/Barrow Neurological Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Operations Manager

Study Record Dates

• First Submitted: March 5, 2015
• First Posted: March 11, 2015
• Study Start: March 1, 2015
• Primary Completion: July 31, 2019
• Study Completion: July 31, 2019
• Last Updated: April 19, 2024

Record last verified: 2024-04

Locations

US (1)