Regular Consumption of High Phytate Reduces Inhibitory Effect of Phytate on Iron Absorption
1 other identifier
interventional
32
0 countries
N/A
Brief Summary
The purpose of this study is to investigate whether regular consumption of phytate dampens its negative effect on nonheme iron absorption.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jan 2013
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2013
CompletedFirst Submitted
Initial submission to the registry
February 11, 2015
CompletedFirst Posted
Study publicly available on registry
February 25, 2015
CompletedFebruary 25, 2015
February 1, 2015
3 months
February 11, 2015
February 19, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Area under the curve for serum iron for assessing bioavailability
8 weeks
Study Arms (2)
High Phytate Diet
EXPERIMENTALThe high phytate diet group was required to consume a high phytate diet for 8 weeks. The high phytate foods were provided for subjects. They received whole grain ready-to-eat cereals, whole wheat pasta/spaghetti, tortillas, bagels, bread and dinner rolls, corn tortillas, brown rice, canned black beans, edamame and tofu, and were encouraged to consume generous amounts of nuts and other legume products high in phytate.
Low Phytate Diet
EXPERIMENTALThe low phytate diet group was required to consume a low phytate diet for 8 weeks. They received foods similar to those for the high phytate diet group but which were made from refined wheat and white rice, eggs and cheese, and were instructed to avoid high phytate foods.
Interventions
Eligibility Criteria
You may qualify if:
- Marginal iron status (Serum ferritin \<30ug/L)
- BMI in the range 18.5-24.9kg/m2
- Willing to modify diet to increase or decrease phytate intake
- Willing to give multiple blood samples at beginning and end of study
You may not qualify if:
- Pregnant
- Lactating
- Smoker
- Anemic (hemoglobin \<120 g/L)
- Has gastro-intestinal disease/condition that can affect absorption
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Iowa State Universitylead
- HarvestPluscollaborator
Related Publications (1)
Armah SM, Boy E, Chen D, Candal P, Reddy MB. Regular Consumption of a High-Phytate Diet Reduces the Inhibitory Effect of Phytate on Nonheme-Iron Absorption in Women with Suboptimal Iron Stores. J Nutr. 2015 Aug;145(8):1735-9. doi: 10.3945/jn.114.209957. Epub 2015 Jun 3.
PMID: 26041677DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Manju B Reddy, PhD
Iowa State University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 11, 2015
First Posted
February 25, 2015
Study Start
January 1, 2013
Primary Completion
April 1, 2013
Study Completion
April 1, 2013
Last Updated
February 25, 2015
Record last verified: 2015-02