A Study of Nelfinavir Added to Cisplatin Chemotherapy Concurrent With Pelvic Radiation for Locally Advanced Cervical Cancer (II-IVA)

NCT02363829 | Completed Phase 1 DMC

• 1 other identifier: UPCC 32814
• Study Type: interventional
• Target: 6
• Locations: 1 country
• Sites: 1

Brief Summary

Patients 18 years of age and older with clinical stages IIA, IIB, IIIA, IIIB, IVA cervical carcinoma limited to the pelvis will receive twice daily oral nelfinavir (NFV) and weekly IV cisplatin in combination as radiosensitizers with daily whole pelvic external beam and intracavitary radiation brachytherapy.

Conditions

Uterine Cervix Cancer

Keywords

clinical stages IIA, IIB, IIIA, IIIB, IVA; invasive carcinoma; uterine cervix

Outcome Measures

Primary Outcomes (1)

• Number of Adverse Events

  2 years

Study Arms (1)

Treatment

EXPERIMENTAL

Nelfinavir and Cisplatin

Drug: Nelfinavir; Biological: Cisplatin

Interventions

Nelfinavir DRUG

Treatment

Cisplatin BIOLOGICAL

Treatment

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All patients with primary, previously untreated, histologically confirmed invasive carcinoma of the uterine cervix (any cell type). Clinical stages IIA, IIB, IIIA, IIIB, IVA. A representative H \& E stained slide showing documentation of the primary invasive cancer is required.
• Patients must have adequate bone marrow, renal and hepatic function:
• Laboratory work must be performed within 30 days prior to start of study treatment.
• ANC ≥ 1,500/μL; Platelet count ≥ 100,000/μL; Creatinine \< 2.0 mg/dL; Total Bilirubin ≤ 1.5 times normal; SGOT ≤ 3 times normal.
• Patients with a ECOG/GOG Performance Status of 0, 1, or 2.
• Patients with ureteral obstruction must be treated with stent or nephrostomy tube.
• Patients of childbearing potential must use an effective form of birth control."Patients receiving oral contraceptives should be instructed that alternate or additional contraceptive measures should be used during therapy with VIRACEPT. "
• Confirmed seronegative HIV status within 3 months prior to start of study treatment.
• Patients must be at least 18 years of age.
• Patients must have signed an approved informed consent and authorization permitting release of personal health information.

You may not qualify if:

• Patients with Stage IA, IB or IVB disease.
• Patients who have known metastases to other organs outside the radiation field at the time of the original clinical and surgical staging.
• Patients who have received previous pelvic or abdominal radiation, cytotoxic chemotherapy, or previous therapy of any kind for this malignancy.
• Patients with septicemia or severe infection.
• Patients who have circumstances that will not permit completion of this study or the required follow-up.
• Patients who are pregnant at the time of diagnosis and do not wish pregnancy termination prior to initiation of treatment.
• Patients with renal abnormalities, such as pelvic kidney, horseshoe kidney, or renal transplantation, that would require modification of radiation fields.
• Patients with other concomitant malignancies (with the exception of non-melanoma skin cancer), who had (or have) any evidence of other cancer present within the last 5 years.
• Patients with GI tract disease resulting in an inability to take oral medication, malabsorption syndrome, a requirement for IV alimentation, prior surgical procedures affecting absorption, uncontrolled inflammatory GI disease (e.g., Crohn's, ulcerative colitis).
• Patients with poorly controlled diabetes mellitus despite medication.
• Patients taking anti-arythmic agents such as amiodarone, quinidine, rifampin, ergot derivatives such as ergotamine, St John's Wort, HMG-CoA reductase inhibitors such as lovastatin, neuroleptic such as pimozide, sedatives such as midazolam and triazolam among other CYP3A4 and CYP2C19 substrates.
• Patients with Phenylketonuria

Sponsors & Collaborators

• Abramson Cancer Center at Penn Medicine: lead

Study Sites (1)

Abramson Cancer Center of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

MeSH Terms

Conditions

Uterine Cervical Neoplasms; Acidemia, isovaleric

Interventions

Nelfinavir; Cisplatin

Condition Hierarchy (Ancestors)

Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Uterine Cervical Diseases; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Intervention Hierarchy (Ancestors)

Isoquinolines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Chlorine Compounds; Inorganic Chemicals; Nitrogen Compounds; Platinum Compounds

Study Officials

• Fiona Simpkins, MD

  Abramson Cancer Center at Penn Medicine

  PRINCIPAL INVESTIGATOR

• Lilie Lin, MD

  Abramson Cancer Center at Penn Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2015
• First Posted: February 16, 2015
• Study Start: February 1, 2015
• Primary Completion: February 17, 2020
• Study Completion: February 17, 2020
• Last Updated: April 6, 2020

Record last verified: 2020-04

Locations

US (1)