Metabolic Exercise Testing

NCT02362685 | Recruiting

• 1 other identifier: RANNOU
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected. Exercise increases the concentration of muscle metabolites in the venous blood supply (e.g. lactate, pyruvate, and ammonia) especially during recovery. The purpose of this study is to compare the results of exercise testing with to the data from muscle biopsy or genetic analysis.

Conditions

Metabolic Myopathies; Exercise Test; Myalgia

Keywords

Metabolic myopathies; Exercise testing; Blood sample; Muscle biopsy; Genetic analysis; Cycloergometer; Grip-test; Exercise physiology; Muscle physiology

Outcome Measures

Primary Outcomes (3)

• Whole-body dynamic exercise

  The relation between Cardiopulmonary exercise test variables and the results of muscle biopsy or genetic analysis will be evaluated.

  Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed

• Grip-test

  The relation between Grip-test variables and the results of muscle biopsy or genetic analysis will be evaluated.

  Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed

• Blood tests

  The results of blood analysis from samples performed before, during, and after exercise will be compared to the results of muscle biopsy or genetic analysis.

  Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed

Study Arms (1)

metabolic exercise testing

All the subjects referred to performed a metabolic exercise testing.

Device: functional test; Genetic: matching genotype with phenotype

Interventions

functional test DEVICE

subjects perform a metabolic exercise testing

metabolic exercise testing

matching genotype with phenotype GENETIC

metabolic exercise testing

Eligibility Criteria

• Age: 5 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects referred to perform a metabolic exercise testing.

You may qualify if:

• Referred to the Physiology Department of Brest Hospital for a metabolic exercise test
• Ability to provide informed consent

You may not qualify if:

• Contraindication(s) to perform cardiopulmonary exercise testing (ATS/ACCP statement on cardiopulmonary exercise testing, Am J respi Care Med 167: 211-77, 2003)
• Pregnancy or unknown pregnancy status.

Sponsors & Collaborators

• University Hospital, Brest: lead

Study Sites (1)

Centre Hospitalier Régional Universitaire

Brest, 29609, France

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood sample Urine sample Muscle tissue DNA

MeSH Terms

Conditions

Myalgia

Interventions

Phenotype

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Diseases; Nervous System Diseases; Musculoskeletal Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Genetic Phenomena

Study Officials

• Fabrice Rannou, MD, PhD

  CHRU Brest

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Fabrice Rannou, MD, PhD

CONTACT

33(0)298347366; fabrice.rannou@chu-brest.fr

Fabrice Rannou, MD, PhD

CONTACT

33(0)298347366; fabrice.rannou@univ-brest.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: February 4, 2015
• First Posted: February 13, 2015
• Study Start: September 1, 2008
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: January 22, 2020

Record last verified: 2020-01

Locations

FR (1)