Antimicrobial Photodynamic Therapy Applied in Orthodontic. Orthodontic Patients.
Oral Decontamination Using Antimicrobial Photodynamic Therapy Applied in Orthodontic Patients.
1 other identifier
interventional
24
1 country
1
Brief Summary
We demonstrated the use of the Antimicrobial Photodynamic Therapy as a coadjutant oral decontamination agent. It was also shown that SDS surfactant improves the antibacterial action of APDT when using Curcumin as the photosensitizer. The decontamination levels obtained with APDT are comparable with the levels observed with the use of Chlorhexidine. The clinical relevancy is the control of oral microbial load which will improve the patients' quality of life and will decrease the possibility of cross contamination in the dental office.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_1
Started Jan 2014
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2014
CompletedFirst Submitted
Initial submission to the registry
December 4, 2014
CompletedFirst Posted
Study publicly available on registry
January 13, 2015
CompletedJanuary 13, 2015
January 1, 2015
5 months
December 4, 2014
January 8, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Microbiological analysis by the total number of colony-forming units (CFU)
one section ( one hour)
Study Arms (7)
Group 1
EXPERIMENTALNegative control - Moutwash with 1,5mL of dimethyl sulfoxide at 5% (DMSO) in water solution - During 2 minutes.
Group 2
EXPERIMENTALMouthwash with Swish with Curcumin
Group 3
EXPERIMENTALMoutwash with Swish with Curcumin + SDS
Group 4
EXPERIMENTALExperiment use dental irradiation with blue light (LED) only.
Group 5
EXPERIMENTALAntimicrobial Photodynamic Therapy (APDT) with blue light and Curcumin salt.
Group 6
EXPERIMENTALAntimicrobial Photodynamic Therapy (APDT) with blue light, Curcumin salt and surfactant.
Group 7
EXPERIMENTALPositive control - Use of mouthwash with Chlorhexidine only
Interventions
Eligibility Criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Vitor Hugo Panhóca
São Carlos, São Paulo, 13560-970, Brazil
Related Publications (1)
Iliadi A, Baumgartner S, Athanasiou AE, Eliades T, Eliades G. Effect of intraoral aging on the setting status of resin composite and glass ionomer orthodontic adhesives. Am J Orthod Dentofacial Orthop. 2014 Apr;145(4):425-33. doi: 10.1016/j.ajodo.2013.11.020.
PMID: 24703280RESULT
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Vitor H Panhóca, Ms
University of Sao Paulo
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Vitor Hugo Panhóca
Study Record Dates
First Submitted
December 4, 2014
First Posted
January 13, 2015
Study Start
January 1, 2014
Primary Completion
June 1, 2014
Study Completion
December 1, 2014
Last Updated
January 13, 2015
Record last verified: 2015-01