Effects of Curcumin on Vascular Reactivity
CURCUMIN
Effects of Curcumin Loading Dose on Vascular Reactivity of Healthy Middle-aged Smokers
1 other identifier
interventional
21
1 country
1
Brief Summary
The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_1
Started Feb 2012
Shorter than P25 for phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2012
CompletedFirst Submitted
Initial submission to the registry
February 16, 2012
CompletedFirst Posted
Study publicly available on registry
March 5, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2012
CompletedJuly 8, 2014
July 1, 2014
2 months
February 16, 2012
July 4, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Changes in brachial Flow Mediated Dilatation
at Visit 1 (Day 0) and visit 2 (Day3/day5)
Secondary Outcomes (2)
Changes in fingertip arterial tonometry
at visit 1 (day 0) and visit 2 (day3/day5)
Modifications of leukocytes transcriptome
at visit 1 (day 0) and visit 2 (day3/day 5)
Study Arms (1)
curcumin
OTHERThe aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk
Interventions
The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk
Eligibility Criteria
You may qualify if:
- to 70 year-old volunteers
- smokers
You may not qualify if:
- treated hypertension
- treated hypercholesterolemia
- chronic disease
- vegetarian or other unusual diets
- chronic alcoholism
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France
Related Publications (1)
Barber-Chamoux N, Milenkovic D, Verny MA, Habauzit V, Pereira B, Lambert C, Richard D, Boby C, Mazur A, Lusson JR, Dubray C, Morand C. Substantial Variability Across Individuals in the Vascular and Nutrigenomic Response to an Acute Intake of Curcumin: A Randomized Controlled Trial. Mol Nutr Food Res. 2018 Mar;62(5). doi: 10.1002/mnfr.201700418. Epub 2018 Feb 12.
PMID: 29034576DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jean-René LUSSON
University Hospital, Clermont-Ferrand
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 16, 2012
First Posted
March 5, 2012
Study Start
February 1, 2012
Primary Completion
April 1, 2012
Study Completion
April 1, 2012
Last Updated
July 8, 2014
Record last verified: 2014-07