Investigation of the Effect of 8-week Controlled High Intense Interval Training in Type 2 Diabetic Patients

NCT02333734 | Completed DMC

• 2 other identifiers: T2D-trainingAarhus University
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

The overall objective of this study is to examine the blood flow in the thigh muscles and sugar metabolism before and after 8 weeks of high intensity interval training (HIIT) on a bicycle ergometer in patients with type 2 diabetes (T2D) and matched controls. The following parameters are included in the assessment:

• Sugar Metabolism
• Muscle and fat mass
• The blood flow at rest around the thigh muscles
• Oxygen uptake test on a bicycle ergometer and 5 km time trial

Conditions

Type 2 Diabetes

Keywords

Type 2 diabetes; Interval training; Insulin resistance; fat metabolism

Outcome Measures

Primary Outcomes (1)

• Oral Glucose tolerance test (OGTT)

  Change from baseline and 8 weeks in glucose/insulin response from a 2.5 hours oral glucose tolerance test (iAUC) after 8 weeks training

  baseline and 8 weeks

Secondary Outcomes (1)

• Physical fitness

  baseline and 8 weeks

Other Outcomes (2)

• Muscle and fat mass

  baseline and 8 weeks

• blood flow

  baseline and 8 weeks

Study Arms (2)

Type 2 diabetic subjects

EXPERIMENTAL

Type 2 diabetic subjects physical training (interval training 3 times at week) in a period of 8 weeks.

Other: Physical training

Healthy subjects

EXPERIMENTAL

Healthy subjects physical training (interval training 3 times at week) in a period of 8 weeks.

Other: Physical training

Interventions

Physical training OTHER

Performed supervised high intensity interval training 3 times a week over 8 weeks on a bicycle ergometer (with watt meter). During the training period, the trainee individually established program, each time with 10 × 60 sec. workout (interspersed with 60 sec. break) corresponding to a force which during the test cycle induces \~ 90% of the maximum heart rate. The time spent per session is expected to last \~ 25 minutes.

Healthy subjects; Type 2 diabetic subjects

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Type 2 diabetes or matched healthy controls. T2D subject only : HbA1c \> 7,3. All subjects have an age between 40-65 years and a body mass index between 25-40 kg/m2. Both genders is allowed

You may not qualify if:

• Severe diseases /immobility

Sponsors & Collaborators

• Aarhus University Hospital: lead

Study Sites (1)

Aarhus Universityhospital, Aarhus University

Aarhus C, 8000, Denmark

Location

Related Publications (1)

• Madsen SM, Thorup AC, Overgaard K, Jeppesen PB. High Intensity Interval Training Improves Glycaemic Control and Pancreatic beta Cell Function of Type 2 Diabetes Patients. PLoS One. 2015 Aug 10;10(8):e0133286. doi: 10.1371/journal.pone.0133286. eCollection 2015.

  PMID: 26258597 DERIVED

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Insulin Resistance

Interventions

Physical Conditioning, Human

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Hyperinsulinism

Intervention Hierarchy (Ancestors)

Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Associate Prof. PhD

Study Record Dates

• First Submitted: July 8, 2014
• First Posted: January 7, 2015
• Study Start: July 1, 2014
• Primary Completion: December 1, 2014
• Study Completion: December 1, 2014
• Last Updated: February 3, 2015

Record last verified: 2015-02

Locations

DK (1)