Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions

NCT02323672 | Completed

• 1 other identifier: chemerin_MMP-9_Oral_cancer
• Study Type: observational
• Target: 45
• Locations: 0 countries
• Sites: N/A

Brief Summary

45 individuals were subdivided into 3 groups, 15 patients with oral premalignant lesions, 15 patients with oral malignant lesions and 15 control individuals. Levels of chemerin and MMP-9 were evaluated in serum and saliva of these subjects utilizing the ELISA technique.

Conditions

Precancerous Conditions; Oral Cancer

Outcome Measures

Primary Outcomes (1)

• salivary levels of chemerin in patients with oral premalignant and malignant lesions.

  1 day

Secondary Outcomes (3)

• serum levels of chemerin in patients with oral premalignant and malignant lesions.

  1 day

• serum levels of MMP-9 in patients with oral premalignant and malignant lesions.

  morning visit

• salivary levels of MMP-9 in patients with oral premalignant and malignant lesions.

  1 day

Study Arms (3)

oral premalignant patients

15 patients suffering from oral premalignant lesions as lichen planus, actinic keratosis, leukoplakia and erythroplakia.

oral malignant patients

15 patients suffering from oral malignant lesions

control subjects

15 individuals age, gender and periodontal status matched with oral premalignant and malignant patients and not suffering from any oral mucosal lesions or periodontal disease.

Eligibility Criteria

• Age: 40 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

45 individuals were subdivided into 3 groups, 15 patients suffering from oral squamous cell carcinoma lesions, 15 patients suffering from oral premalignant lesions (OPL) and 15 individuals having age, gender and periodontal status matched with both patients groups acting as a control group.

You may qualify if:

• patients with oral premalignant lesions.
• patients with oral malignant lesions.

You may not qualify if:

• any systemic disease other than oral premalignant or malignant lesions. smokers. pregnant females. periodontal diseases.

Sponsors & Collaborators

• Cairo University: lead

Related Publications (5)

• Skrzeczynska-Moncznik J, Stefanska A, Zabel BA, Kapinska-Mrowiecka M, Butcher EC, Cichy J. Chemerin and the recruitment of NK cells to diseased skin. Acta Biochim Pol. 2009;56(2):355-60. Epub 2009 Jun 18.

  PMID: 19543554 BACKGROUND

• Parolini S, Santoro A, Marcenaro E, Luini W, Massardi L, Facchetti F, Communi D, Parmentier M, Majorana A, Sironi M, Tabellini G, Moretta A, Sozzani S. The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues. Blood. 2007 May 1;109(9):3625-32. doi: 10.1182/blood-2006-08-038844. Epub 2007 Jan 3.

  PMID: 17202316 BACKGROUND

• Zhou XJ, Sugerman PB, Savage NW, Walsh LJ. Matrix metalloproteinases and their inhibitors in oral lichen planus. J Cutan Pathol. 2001 Feb;28(2):72-82. doi: 10.1034/j.1600-0560.2001.280203.x.

  PMID: 11168755 BACKGROUND

• Nanda DP, Dutta K, Ganguly KK, Hajra S, Mandal SS, Biswas J, Sinha D. MMP-9 as a potential biomarker for carcinoma of oral cavity: a study in eastern India. Neoplasma. 2014;61(6):747-57. doi: 10.4149/neo_2014_091.

  PMID: 25150320 BACKGROUND

• Wang N, Wang QJ, Feng YY, Shang W, Cai M. Overexpression of chemerin was associated with tumor angiogenesis and poor clinical outcome in squamous cell carcinoma of the oral tongue. Clin Oral Investig. 2014 Apr;18(3):997-1004. doi: 10.1007/s00784-013-1046-8. Epub 2013 Jul 19.

  PMID: 23868294 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum and whole unstimulated saliva

MeSH Terms

Conditions

Precancerous Conditions; Mouth Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Noha Ghallab, M.D.

  Associate Professor of periodontology and Oral Medicine faulty of oral and dental medicine Cairo Unv.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of periodontology and Oral Medicine, faculty of oral and dental medicine

Study Record Dates

• First Submitted: December 18, 2014
• First Posted: December 23, 2014
• Study Start: February 1, 2014
• Primary Completion: September 1, 2014
• Study Completion: October 1, 2014
• Last Updated: February 10, 2017

Record last verified: 2017-02