The Role of Neural Systems for Emotion Regulation in Coping With Alcohol Craving

NCT02316574 | Completed DMC

• 1 other identifier: #6859
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Cognitive Behavioral Coping Skills Therapy (CBCST) is a commonly utilized, evidence-based psychosocial therapy (talk therapy) for alcohol dependence. By identifying the neural mechanisms through which CBCST changes drinking behavior, it may be possible to improve its efficacy. CBCST promotes abstinence by teaching "coping skills" for managing alcohol-related thoughts and emotions. In this pilot study, the investigators examine the neural systems that play a role in the learning of coping skills through CBCST, specifically focusing on the role of emotion regulation systems.

Conditions

Alcoholism

Keywords

Alcohol dependence; Cognitive Behavioral Therapy; Functional neuroimaging

Outcome Measures

Primary Outcomes (1)

• Percent heavy drinking days

  Assessed during the weekly CBCST treatment

  12 weeks

Study Arms (1)

Cognitive Behavioral Coping Skills

EXPERIMENTAL

Cognitive Behavioral Coping Skills Therapy is an individual psychotherapy for alcohol use disorders that has been previously shown to reduce drinking. The focus of this treatment is the teaching of coping skills for managing alcohol craving and negative emotions as a way to reduce drinking behavior.

Behavioral: Cognitive Behavioral Coping Skills Therapy

Interventions

Cognitive Behavioral Coping Skills Therapy BEHAVIORAL

Cognitive Behavioral Coping Skills Therapy (CBCST) is an individual psychotherapy for alcohol dependence that helps individuals to reduce drinking by addressing the ability to regulate, or "cope" with alcohol cravings and other emotions that promote alcohol use.

Also known as: Cognitive Behavioral Therapy, Relapse Prevention Therapy

Cognitive Behavioral Coping Skills

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Right-handed
• Meets DSM-V criteria for current Alcohol Use Disorder
• Currently drinking \>5/4 or more drinks/day for men/women in the last 28 day, on average, at the time of initial screening visit.
• Current goal of moderating or abstaining from drinking alcohol
• Seeking treatment for Alcohol Use Disorder
• Agree to not seek additional treatment, apart from Alcoholics Anonymous
• English-speaking and able to provide informed consent and comply with study procedures
• Willing to abstain from alcohol completely for 24 hours on 3 separate occasions

You may not qualify if:

• Any current Moderate or Severe substance use disorder, other than alcohol, nicotine or caffeine use disorders.
• Lifetime history of Bipolar Disorder, Schizophrenia or Schizoaffective Disorder
• A diagnosis of any current psychiatric disorder other than Alcohol Use Disorder (e.g. Major Depressive Disorder, Generalized Anxiety Disorder) that in the investigator's judgment might require intervention with either pharmacological or non-pharmacological therapy over the course of the study.
• History of severe alcohol withdrawal (e.g. seizure, delirium tremens, multiple detoxifications or ER visits for alcohol withdrawal)
• Significant risk for suicide or violence
• Legally mandated to receive treatment
• Sufficiently socially unstable as to preclude study participation (e.g. homeless).
• Currently taking any psychotropic medications.
• Significant cognitive impairment
• Neurological or medical conditions that would interfere with MRI scanning (e.g. history of stroke, seizure, brain tumor, brain infection, multiple sclerosis, metal device in body, pregnancy, claustrophobia)

Sponsors & Collaborators

• New York State Psychiatric Institute: lead

Study Sites (1)

NYPInstitute

New York, New York, 10032, United States

Location

Related Publications (1)

• Srivastava AB, Sanchez-Pena J, Levin FR, Mariani JJ, Patel GH, Naqvi NH. Drinking reduction during cognitive behavioral therapy for alcohol use disorder is associated with a reduction in anterior insula-bed nucleus of the stria terminalis resting-state functional connectivity. Alcohol Clin Exp Res. 2021 Aug;45(8):1596-1606. doi: 10.1111/acer.14661. Epub 2021 Aug 2.

  PMID: 34342012 DERIVED

MeSH Terms

Conditions

Alcoholism

Interventions

Cognitive Behavioral Therapy; Secondary Prevention

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities; Therapeutics; Preventive Health Services; Health Services; Health Care Facilities Workforce and Services; Public Health Practice; Public Health; Environment and Public Health

Study Officials

• Nasir H. Naqvi, MD, PhD

  Assistant Professor of Pscyhiatry

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: research psychiatrist

Study Record Dates

• First Submitted: December 10, 2014
• First Posted: December 15, 2014
• Study Start: December 1, 2014
• Primary Completion: January 1, 2021
• Study Completion: January 1, 2021
• Last Updated: July 2, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)