NCT02315170

Brief Summary

To determine if a novel intraocular injection guide (IIG) reduces patient discomfort during and after intravitreal injections.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Sep 2014

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2014

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

December 9, 2014

Completed
2 days until next milestone

First Posted

Study publicly available on registry

December 11, 2014

Completed
21 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2015

Completed
6.3 years until next milestone

Results Posted

Study results publicly available

May 5, 2021

Completed
Last Updated

May 5, 2021

Status Verified

May 1, 2021

Enrollment Period

4 months

First QC Date

December 9, 2014

Results QC Date

September 18, 2020

Last Update Submit

May 3, 2021

Conditions

Keywords

diabetic retinopathyage-related macular edema

Outcome Measures

Primary Outcomes (1)

  • Visual Analogue Scale (VAS)

    The VAS is a horizontal line, 100 mm in length, and anchored by word descriptors at each end. The scale scores range from 0mm (no pain) to 100mm (very severe pain). The patient marks on the line the point that they feel represents their perception of their current state (no pain to very severe pain).

    one time for about 30 sec or less

Study Arms (2)

intraocular injection guide

EXPERIMENTAL

novel intraocular injection guide is a long, tubular structure consisting of a non-moldable material with a single internal opening. There is a 2x2 square hole located at the bottom of the device where the needle exits the guide and enters the eye

Device: intraocular injection guide

standard lid speculum

ACTIVE COMPARATOR

Standard wire eyelid speculum

Device: standard lid speculum

Interventions

The device is 35mm long with tapered edges for an easy grip and it aligns with the curvature of the cornea to ensure that needle entry takes place at the optimal distance for injection

intraocular injection guide

standard wire lid speculum

standard lid speculum

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Subjects must be receiving bilateral injections of the same dose of vascular endothelial growth factor (VEGF) inhibitor
  • Injections in both eyes must be given on the same day
  • Male or female age 18 years or older

You may not qualify if:

  • Any condition or reason that precludes the subject's ability to comply with the study -

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Raj K Maturi MD PC

Indianapolis, Indiana, 46290, United States

Location

MeSH Terms

Conditions

Retinal DiseasesDiabetic Retinopathy

Condition Hierarchy (Ancestors)

Eye DiseasesDiabetic AngiopathiesVascular DiseasesCardiovascular DiseasesDiabetes ComplicationsDiabetes MellitusEndocrine System Diseases

Limitations and Caveats

This is a small one event study (about 10 min duration). The participant evaluates which speculum (used for about 30 sec or less) during the procedure provides better comfort. Thus, long term evaluation has not been peformed.

Results Point of Contact

Title
Raj K Maturi MD
Organization
Raj K M

Study Officials

  • Raj K Maturi, MD

    Raj K. Maturi, MD, PC

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
INDIV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
President

Study Record Dates

First Submitted

December 9, 2014

First Posted

December 11, 2014

Study Start

September 1, 2014

Primary Completion

January 1, 2015

Study Completion

January 1, 2015

Last Updated

May 5, 2021

Results First Posted

May 5, 2021

Record last verified: 2021-05

Locations