Reoxygenation After Cardiac Arrest (REOX Study)
REOX
2 other identifiers
observational
280
1 country
5
Brief Summary
The broad objective of this study is to test the association between hyperoxia exposure after resuscitation from cardiac arrest and outcome. Our overarching hypothesis is that hyperoxia after ROSC is associated with increased oxidative stress and worsened neurological and cognitive outcomes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2013
Longer than P75 for all trials
5 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2013
CompletedFirst Submitted
Initial submission to the registry
June 17, 2013
CompletedFirst Posted
Study publicly available on registry
June 19, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2017
CompletedNovember 25, 2019
November 1, 2019
4 years
June 17, 2013
November 22, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Plasma isoprostanes/isofurans (mechanistic outcome)
0 and 6 hours post-ROSC
Secondary Outcomes (1)
Modified Rankin Scale (mRS) (primary neurological outcome)
hospital discharge
Other Outcomes (1)
Cognitive testing (primary neuropsychological outcome)
180 days
Study Arms (1)
Adult patients resuscitated from cardiac arrest
Eligibility Criteria
Adult patients resuscitated from cardiac arrest
You may qualify if:
- Age \>17 years
- Cardiac arrest
- Return of spontaneous circulation
- Not following commands immediately after ROSC
- Endotracheal intubation
- Clinician intent to treat with therapeutic hypothermia (or absence of clinician intent to withhold therapeutic hypothermia)
You may not qualify if:
- Presumed etiology of arrest is trauma
- Presumed etiology of arrest is hemorrhage
- Presumed etiology of arrest is sepsis
- Permanent resident of nursing home or other long-term care facility
- Any other condition, that in the opinion of the investigator, would preclude the subject from being a suitable candidate, e.g. end stage chronic illness with no reasonable expectation of survival to hospital discharge
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (5)
Indiana University/ Methodist Hospital
Indianapolis, Indiana, 46202, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
Cooper University Hospital
Camden, New Jersey, 08103, United States
Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104, United States
Biospecimen
This research will measure biomarkers of oxidative stress (isoprostanes and isofurans) on plasma samples.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Stephen Trzeciak, MD, MPH
The Cooper Health System
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 17, 2013
First Posted
June 19, 2013
Study Start
June 1, 2013
Primary Completion
June 1, 2017
Study Completion
June 1, 2017
Last Updated
November 25, 2019
Record last verified: 2019-11