Transthoracic Echocardiographic Evaluation of the Cardiac Function During Transurethral Resection of Prostate in Elderly Patients

NCT02288780 | Terminated

• 1 other identifier: 4-2014-0734
• Study Type: observational
• Target: 2
• Locations: 0 countries
• Sites: N/A

Brief Summary

Transurethral resection of the prostate (TURP) is a standard surgical treatment for benign prostatic hyperplasia (BPH). Non-conductive irrigation fluid is used to maintain good visibility of the operating field during resection of the prostate. Absorption of this hypotonic solution into the bloodstream can cause fluid overload and dilutional hyponatremia, resulting in adverse cardiovascular and central nervous system effects, transurethral resection (TUR) syndrome. BPH is common in elderly men above 60 years old. These aged people commonly have diastolic impairment by normal physiologic change without consistent symptom. This study aimed to evaluate the cardiac function focused mainly diastolic function during TURP with transthoracic echocardiography. Also, we will focus the effets of amount of irrgation fluid on left ventricular diastolic function in patients with pre-existing diastolic dysfunction.

Conditions

BPH

Outcome Measures

Primary Outcomes (1)

• diastolic function by TTE

  The participants will be followed for the duration of surgery (TURP), an expected average of 1 hour.

Study Arms (2)

Control

BPH patients with normal diastolic function

Diastolic dysfunction

BPH patients with preoperative diastolic dysfunction

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

BPH patients with/without preoperative diastolic dysfunction

You may qualify if:

• Above 65years of age
• American Society of Anesthesiologists (ASA) Physical Status I, II, III.
• undergoing transurethral resection of the prostate(TURP)"

You may not qualify if:

• severe coagulopathy or bleeding disorder(platelet count\<75000, PT INR \>1.2)
• short stature (under 150 cm)
• underwent coronary artery bypass graft
• contraindications of regional anesthesia "

Sponsors & Collaborators

• Yonsei University: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 30, 2014
• First Posted: November 11, 2014
• Study Start: December 1, 2014
• Primary Completion: May 1, 2015
• Study Completion: May 1, 2015
• Last Updated: March 18, 2019

Record last verified: 2019-03