Global Strain and Mechanical Dispersion May Predict Death and Ventricular Arrhythmias Better Than Ejection Fraction
Improved Prediction of Clinical Outcome With the Use of Global Strain and Mechanical Dispersion in Patients With Myocardial Infarction and Heart Failure
1 other identifier
observational
3,100
2 countries
8
Brief Summary
The aim of the study is to investigate if global strain and mechanical dispersion may predict death and ventricular arrhythmias better than ejection fraction(EF) in patients with myocardial infarction and heart failure regardless of cause.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2014
Longer than P75 for all trials
8 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2014
CompletedFirst Submitted
Initial submission to the registry
August 22, 2014
CompletedFirst Posted
Study publicly available on registry
November 10, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2025
CompletedNovember 13, 2023
November 1, 2023
11.5 years
August 22, 2014
November 7, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Ventricular arrhythmia and death after acute myocardial infarction or heart failure.
Arrhythmic events during follow-up are defined as documented sustained ventricular tachycardia, ventricular fibrillation, and SCD. Survival is assessed by medical charts if patients are within the uptake area of the hospital and by the Norwegian death registry Folkeregisteret.
5 years or more
Eligibility Criteria
Patients with myocardial infarction, heart failure and patients planned for primary prophylactic ICD. Echocardiography is performed at inclusion. Comparism of the ability of left ventricular ejection fraction, global strain and mechanical dispersion to predict clinical outcome in patients with these conditions.
You may qualify if:
- All patients with
- myocardial infarction
- heart failure( defined as heart failure symptoms: reduced left ventricular function/ and or heart failure signs on chest x ray.
- planned for primary prophylactic ICD
- over 18 years of age
- Informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (8)
Vseobecna fakultni nemocnice Praha/ Prague General hospital
Prague, Czechia
Sørlandet sykehus HF
Arendal, Agder, 4800, Norway
Vestre Viken HF
Drammen, 3004, Norway
Sørlandet sykehus Kristiansand
Kristiansand, 4604, Norway
Oslo university hospital
Oslo, Norway
Sykehuset Telemark HF
Skien, 3710, Norway
Stavanger universitetssjukehus
Stavanger, 4068, Norway
Universitetssykehuset Nord Norge, Tromsø
Tromsø, 9038, Norway
Study Officials
- STUDY DIRECTOR
Thor Edvardsen, MD, PHD
Oslo University Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor, Chief department of Cardiology Oslo university hospital
Study Record Dates
First Submitted
August 22, 2014
First Posted
November 10, 2014
Study Start
June 1, 2014
Primary Completion
December 1, 2025
Study Completion
December 1, 2025
Last Updated
November 13, 2023
Record last verified: 2023-11