Low Load, High-repetitive Elastic Band Resistance Training in COPD

NCT02283580 | Completed

• 1 other identifier: LLHR-COPD-2014
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 2

Brief Summary

Recent work have shown that low load, high-repetitive single limb resistance training, if compared to a control, can increase limb muscle function and functional exercise capacity in patients with chronic obstructive pulmonary disease (COPD) while avoiding the occurrence of limiting exertional symptoms. However, no comparison to another exercise regimen have been performed. In addition neither the intramuscular nor the mechanism of this exercise regimen have been investigated and represents the aim of the proposed project. We will in a prospective, assessor-blind; block randomized controlled, parallel-group trial compare single-limb to two-limb low load, high-repetitive resistance training in patients with severe and very severe COPD The research hypothesizes are:

• that single-limb low-load high-repetitive resistance training will provide larger gain in the 6-min walking distance than two-limb low-load high- repetitive resistance training in patients with severe to very severe (stage III-IV) COPD.
• that eight weeks of single limb training should also be associated with larger physiological (increased muscle endurance, less muscle fatigue and deoxygenation) and structural (muscle protein synthesis, fiber-type distribution and capillarization) muscle adaptations to training, lower cardio- respiratory demand, as well a greater increase in health-related quality of life in comparison to two-limbs simultaneous training. We will also compare the groups at baseline to investigate the acute effects and mechanisms of single-limb to two-limb low load, high-repetitive resistance training, a comparison that also will include healthy matched controls. The research hypothesizes are:
• that involving a large muscle mass during exercise (e.g., two-limb low load, high-repetition resistance training) compared to involving a small muscle mass during training (e.g., single limb low load, high-repetition resistance training) would lead to larger restraints on the cardiorespiratory system in patients with severe to very severe COPD. Conversely, single limb interventions should produce less dyspnea and more muscle deoxygenation and fatigue than two-limb simultaneous exercise while healthy controls will be able to perform both legs/arms exercise without a central constraint, and no negative consequences on muscle fatigue or exercise stimulus.

Conditions

Pulmonary Disease, Chronic Obstructive; Healthy

Keywords

COPD; Healthy adults; Resistance training; Elastic bands; Limb muscle function; Volunteers

Outcome Measures

Primary Outcomes (1)

• Walking capacity (distance [meters])

  Meters walked on the 6- minute walk test. The walking course will be 30 meters in length and the patients will be instructed in accordance to standardized guidelines to walk as far as possible in 6 minutes. One practice test will be performed to minimize risk of learning effect. The highest walking distance of the two 6-min walks will be chosen as baseline value.

  Baseline (week 0), 8 weeks

Secondary Outcomes (8)

• Unsupported upper extremity endurance capacity (time [seconds])

  Baseline (week 0), 8 weeks

• Isokinetic limb muscle function (Endurance [total work], strength [peak torque])

  Baseline (week 0), 8 weeks

• Ventilatory response

  Baseline (week 0), 8 weeks

• Cardiac output

  Week 0 and week 8

• Muscle deoxygenation

  Baseline (week 0), week 8

Study Arms (2)

Single limb resistance training

EXPERIMENTAL

Low load, high-repetitive resistance training. * single limb at a time (e.g., one arm or one leg) * elastic bands

Other: Single limb

Two limb resistance training

ACTIVE COMPARATOR

Low load, high-repetitive resistance training. * two limbs at a time (e.g., both arms or both legs) * elastic bands

Other: Two limb

Interventions

Single limb OTHER

Low load, high-repetitive resistance training. * single limb at a time (e.g., one arm or one leg) * elastic bands * 8 weeks * 3 times/week, * each session 60 minutes * seven resistance exercises: Latissimus row, leg curl, elbow flexion, chestpress, plantar flexion, shoulder flexion and knee extension * maximal number of repetitions (RM) \* 3 sets in each exercise.

Single limb resistance training

Two limb OTHER

Low load, high-repetitive resistance training. * two limbs at a time (e.g., both arms or both legs) * elastic bands * 8 weeks * 3 times/week, * each session 60 minutes * seven resistance exercises: Latissimus row, leg curl, elbow flexion, chestpress, plantar flexion, shoulder flexion and knee extension * maximal number of repetitions (RM) \* 3 sets in each exercise.

Two limb resistance training

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age: \> 40
• Cumulative (current or ex) smoking history \>10 pack-years
• COPD with non-reversible airflow obstruction corresponding to GOLD 3 and 4

You may not qualify if:

• Recent exacerbation (\< 6 weeks)
• Neuromuscular and/or orthopedic disorders that compromises participation to an exercise program
• Recent cancer
• Unstable cardiac disease and cardiac stimulator
• Asthma
• Low body weight or obesity (Body Mass Index \< 20 Kg/m2 and or \> 30kg/m2)
• Significant hypoxemia at rest (SaO2 \<85%)
• a daily dose \> 10mg of systemic prednisone.
• Age: \> 40
• Normal pulmonary function tests.
• Neuromuscular and/or orthopedic disorders that compromises participation to an exercise program
• Physically active (\>9) according the Voorips questionnaire.

Sponsors & Collaborators

• Laval University: lead
• Saey, Didier, M.D.: collaborator
• Maltais, Francois, M.D.: collaborator

Study Sites (2)

Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)

Québec, Quebec, G1S4V3, Canada

Location

Centre de recherche de l'IUCPQ

Québec, G1V 4G5, Canada

Location

Related Publications (2)

• Nyberg A, Martin M, Saey D, Milad N, Patoine D, Morissette MC, Auger D, Stal P, Maltais F. Effects of Low-Load/High-Repetition Resistance Training on Exercise Capacity, Health Status, and Limb Muscle Adaptation in Patients With Severe COPD: A Randomized Controlled Trial. Chest. 2021 May;159(5):1821-1832. doi: 10.1016/j.chest.2020.12.005. Epub 2020 Dec 13.

  PMID: 33316237 DERIVED

• Nyberg A, Saey D, Martin M, Maltais F. Muscular and functional effects of partitioning exercising muscle mass in patients with chronic obstructive pulmonary disease - a study protocol for a randomized controlled trial. Trials. 2015 Apr 27;16:194. doi: 10.1186/s13063-015-0698-x.

  PMID: 25927288 DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Francois Maltais, MD

  Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)

  PRINCIPAL INVESTIGATOR

• Didier Saey, Pht, PhD

  Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: November 3, 2014
• First Posted: November 5, 2014
• Study Start: November 1, 2014
• Primary Completion: February 1, 2017
• Study Completion: February 1, 2017
• Last Updated: March 7, 2018

Record last verified: 2018-03

Locations

CA (2)