Optical Coherence Tomography Quantitative Analysis of Changes in Anterior Chamber After Laser Peripheral Lridotomy

NCT02279472 | Unknown

• 1 other identifier: SecondXHCSU
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to analysis changes in anterior segment morphology after laser peripheral lrldotomy measured by optical coherence tomography, and to evaluate treatment effectiveness

Conditions

Primary Angle Closure Glaucoma

Outcome Measures

Primary Outcomes (1)

• Changes in anterior chamber after LPI at 1 month

  1month

Study Arms (1)

laser peripheral iridotomy

OTHER

Laser peripheral iridotomy (LPI) is widely regarded as the first-line intervention for either acute or chronic types of angle-closure glaucoma in early stage ,which relieves pupil block and thus flattening the iris contour and widening the drainage angle,performd by Nd.YAG LASER

Procedure: Laserex Tango Nd:YAG, Ellex-SuperQ Medical, Australia

Interventions

Laserex Tango Nd:YAG, Ellex-SuperQ Medical, Australia PROCEDURE

All the patients will be achieved with pilocarpine 1% for pupil constriction, laser peripheral iridotomy(LPI) is performed using the ophthalmic neodymium: yttrium aluminium garnet laser (Laserex Tango Nd:YAG, Ellex-SuperQ Medical, Australia) and an VOLK iridotomy contact lens. After LPI, patients will be given topical prednisolone acetate 0.1% for 7 days.

laser peripheral iridotomy

Eligibility Criteria

• Age: 30 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• The gonioscopy or UBM examination has confirmed the diagnosis of PACS or PAC 2. Intraocular pressure within 10 to 21 mmHg ，C/D≤0.6 3. Visual field is normal or only show paracentral scotoma 4. Vision or corrected visual acuity ≥0.8 5. Refractive degree no more than 200D 6. Exclude other ocular and systemic diseases

You may not qualify if:

• Corneal macula and other corneal diseases, ocular surface disease or corneal edema
• Iridocyclitis
• Ocular trauma and intraocular operation history
• No fixationFundus lesions such as diabetic retinopathy or retinal detachment
• No fixation
• Ocular or systemic application of cortical steroids -

Sponsors & Collaborators

• Second Xiangya Hospital of Central South University: lead

Study Sites (1)

The Second Xiangya Hospital of Central South University,

Changsha, Hunan, 410000, China

RECRUITING

Related Publications (2)

• Memarzadeh F, Li Y, Chopra V, Varma R, Francis BA, Huang D. Anterior segment optical coherence tomography for imaging the anterior chamber after laser peripheral iridotomy. Am J Ophthalmol. 2007 May;143(5):877-9. doi: 10.1016/j.ajo.2006.11.055. Epub 2006 Dec 29.

  PMID: 17452177 BACKGROUND

• Lee KS, Sung KR, Shon K, Sun JH, Lee JR. Longitudinal changes in anterior segment parameters after laser peripheral iridotomy assessed by anterior segment optical coherence tomography. Invest Ophthalmol Vis Sci. 2013 May 3;54(5):3166-70. doi: 10.1167/iovs.13-11630.

  PMID: 23599331 BACKGROUND

MeSH Terms

Conditions

Glaucoma, Angle-Closure

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Study Officials

• Xuanchu Duan, Ph.D

  Second Xiangya Hospital of Central South University

  STUDY DIRECTOR

Central Study Contacts

Haomin Luo, Ph.D student

CONTACT

+86 13875830738; lhmqqpp@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Haomin Luo M.d.

Study Record Dates

• First Submitted: September 30, 2014
• First Posted: October 31, 2014
• Study Start: October 1, 2014
• Primary Completion: December 1, 2014
• Study Completion: January 1, 2015
• Last Updated: October 31, 2014

Record last verified: 2014-10

Locations

CN (1)